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Charting elimination in the pandemic: a SARS-CoV-2 serosurvey of blood donors in New Zealand.
Carlton, Lauren H; Chen, Tiffany; Whitcombe, Alana L; McGregor, Reuben; Scheurich, Greg; Sheen, Campbell R; Dickson, James M; Bullen, Chris; Chiang, Annie; Exeter, Daniel J; Paynter, Janine; Baker, Michael G; Charlewood, Richard; Moreland, Nicole J.
  • Carlton LH; School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
  • Chen T; School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
  • Whitcombe AL; School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
  • McGregor R; School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
  • Scheurich G; The New Zealand Blood Service, Auckland, New Zealand.
  • Sheen CR; Callaghan Innovation, Christchurch, New Zealand.
  • Dickson JM; School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
  • Bullen C; School of Population Health, The University of Auckland, Auckland, New Zealand.
  • Chiang A; School of Population Health, The University of Auckland, Auckland, New Zealand.
  • Exeter DJ; School of Population Health, The University of Auckland, Auckland, New Zealand.
  • Paynter J; School of Population Health, The University of Auckland, Auckland, New Zealand.
  • Baker MG; Department of Public Health, University of Otago, Wellington, New Zealand.
  • Charlewood R; The New Zealand Blood Service, Auckland, New Zealand.
  • Moreland NJ; School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
Epidemiol Infect ; 149: e173, 2021 07 30.
Article in English | MEDLINE | ID: covidwho-1347909
Preprint
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ABSTRACT
New Zealand has a strategy of eliminating SARS-CoV-2 that has resulted in a low incidence of reported coronavirus-19 disease (COVID-19). The aim of this study was to describe the spread of SARS-CoV-2 in New Zealand via a nationwide serosurvey of blood donors. Samples (n = 9806) were collected over a month-long period (3 December 2020-6 January 2021) from donors aged 16-88 years. The sample population was geographically spread, covering 16 of 20 district health board regions. A series of Spike-based immunoassays were utilised, and the serological testing algorithm was optimised for specificity given New Zealand is a low prevalence setting. Eighteen samples were seropositive for SARS-CoV-2 antibodies, six of which were retrospectively matched to previously confirmed COVID-19 cases. A further four were from donors that travelled to settings with a high risk of SARS-CoV-2 exposure, suggesting likely infection outside New Zealand. The remaining eight seropositive samples were from seven different district health regions for a true seroprevalence estimate, adjusted for test sensitivity and specificity, of 0.103% (95% confidence interval, 0.09-0.12%). The very low seroprevalence is consistent with limited undetected community transmission and provides robust, serological evidence to support New Zealand's successful elimination strategy for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Donors / Disease Eradication / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Oceania Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2021 Document Type: Article Affiliation country: S0950268821001643

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Donors / Disease Eradication / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Oceania Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2021 Document Type: Article Affiliation country: S0950268821001643