SARS-CoV-2 Nsp1: Ein kleines Protein blockiert die Immunantwort.
Biospektrum (Heidelb)
; 27(4): 368-371, 2021.
Article
in German
| MEDLINE | ID: covidwho-1349361
ABSTRACT
The Coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To facilitate its own replication and avoid immune control, SARS-CoV-2 manipulates its target cells. Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host's antiviral immune response.
Full text:
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Collection:
International databases
Database:
MEDLINE
Language:
German
Journal:
Biospektrum (Heidelb)
Year:
2021
Document Type:
Article
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