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Obesity as a Risk Factor for Severe COVID-19: Summary of the Best Evidence and Implications for Health Care.
Sattar, Naveed; Valabhji, Jonathan.
  • Sattar N; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK. Naveed.Sattar@glasgow.ac.uk.
  • Valabhji J; NHS England & Improvement, London, UK.
Curr Obes Rep ; 10(3): 282-289, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1349364
ABSTRACT
PURPOSE OF REVIEW To collate the best evidence from several strands-epidemiological, genetic, comparison with historical data and mechanistic information-and ask whether obesity is an important causal and potentially modifiable risk factor for severe COVID-19 outcomes. RECENT

FINDINGS:

Several hundred studies provide powerful evidence that body mass index (BMI) is a strong linear risk factor for severe COVID-19 outcomes, with recent studies suggesting ~5-10% higher risk for COVID-19 hospitalisation per every kg/m2 higher BMI. Genetic data concur with hazard ratios increasing by 14% per every kg/m2 higher BMI. BMI to COVID-19 links differ markedly from prior BMI-infection associations and are further supported as likely causal by multiple biologically plausible pathways. Excess adiposity appears to be an important, modifiable risk factor for adverse COVID-19 outcomes across all ethnicities. The pandemic is also worsening obesity levels. It is imperative that medical systems worldwide meet this challenge by upscaling investments in obesity prevention and treatments.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Body Mass Index / Pandemics / COVID-19 / Obesity Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Curr Obes Rep Year: 2021 Document Type: Article Affiliation country: S13679-021-00448-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Body Mass Index / Pandemics / COVID-19 / Obesity Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Curr Obes Rep Year: 2021 Document Type: Article Affiliation country: S13679-021-00448-8