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Ct Values Do Not Predict Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmissibility in College Students.
Tian, Di; Lin, Zhen; Kriner, Ellie M; Esneault, Dalton J; Tran, Jonathan; DeVoto, Julia C; Okami, Naima; Greenberg, Rachel M; Yanofsky, Sarah; Ratnayaka, Swarnamala; Tran, Nicholas; Livaccari, Maeghan; Lampp, Marla L; Wang, Noel; Tim, Scott; Norton, Patrick; Scott, John; Hu, Tony Y; Garry, Robert; Hamm, Lee; Delafontaine, Patrice; Yin, Xiao-Ming.
  • Tian D; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Lin Z; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Kriner EM; School of Medicine, Services for Campus Health, Tulane University, New Orleans, Louisiana.
  • Esneault DJ; Operation Services, Tulane University, New Orleans, Louisiana.
  • Tran J; Information Technology, Tulane University, New Orleans, Louisiana.
  • DeVoto JC; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Okami N; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Greenberg RM; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Yanofsky S; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Ratnayaka S; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Tran N; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Livaccari M; School of Medicine, Services for Campus Health, Tulane University, New Orleans, Louisiana.
  • Lampp ML; Operation Services, Tulane University, New Orleans, Louisiana.
  • Wang N; Information Technology, Tulane University, New Orleans, Louisiana.
  • Tim S; School of Medicine, Services for Campus Health, Tulane University, New Orleans, Louisiana.
  • Norton P; Operations, Tulane University, New Orleans, Louisiana.
  • Scott J; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana.
  • Hu TY; Department of Biochemistry and Molecule Biology, Tulane University, New Orleans, Louisiana.
  • Garry R; Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana.
  • Hamm L; Department of Medicine, Tulane University, New Orleans, Louisiana.
  • Delafontaine P; Department of Medicine, Tulane University, New Orleans, Louisiana. Electronic address: pdelafon@tulane.edu.
  • Yin XM; Department of Pathology and Laboratory Medicine, Tulane University, New Orleans, Louisiana. Electronic address: xmyin@tulane.edu.
J Mol Diagn ; 23(9): 1078-1084, 2021 09.
Article in English | MEDLINE | ID: covidwho-1386076
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious and has caused significant medical/socioeconomic impacts. Other than vaccination, effective public health measures, including contact tracing, isolation, and quarantine, is critical for deterring viral transmission, preventing infection progression and resuming normal activities. Viral transmission is affected by many factors, but the viral load and vitality could be among the most important ones. Although in vitro studies have indicated that the amount of virus isolated from infected individuals affects the successful rate of virus isolation, whether the viral load carried at the individual level would determine the transmissibility was unknown. We examined whether the cycle threshold (Ct) value, a measurement of viral load by RT-PCR assay, could differentiate the spreaders from the non-spreaders in a population of college students. Our results indicate that while at the population level the Ct value is lower, suggesting a higher viral load, in the symptomatic spreaders than that in the asymptomatic non-spreaders, there is a significant overlap in the Ct values between the two groups. Thus, Ct value, or the viral load, at the individual level could not predict the transmissibility. Instead, a sensitive method to detect the presence of virus is needed to identify asymptomatic individuals who may carry a low viral load but can still be infectious.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Universities / Multiplex Polymerase Chain Reaction / COVID-19 Nucleic Acid Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Young adult Country/Region as subject: North America Language: English Journal: J Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Universities / Multiplex Polymerase Chain Reaction / COVID-19 Nucleic Acid Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Young adult Country/Region as subject: North America Language: English Journal: J Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article