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[A feasibility study on cervical screening in non-attenders invited to undergo HPV self-sampling with cytology triage versus repeat invitation for cytology screening in Hokkaido].
Taniguchi, Shinobu; Sakuragi, Noriaki; Hanley, Sharon J B; Tsukiyama, Kizuna; Fujita, Hiromasa; Sagae, Satoru; Kajii, Naofumi; Watari, Hidemichi; Tamakoshi, Akiko.
  • Taniguchi S; Ebetsu City Public Health Promotion Office Health and Welfare Department.
  • Sakuragi N; Otaru General Hospital Women's Healthcare Center.
  • Hanley SJB; Hokkaido University.
  • Tsukiyama K; General Incorporated Association PCAF.
  • Fujita H; Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine.
  • Sagae S; General Incorporated Association PCAF.
  • Kajii N; Ebetsu City Public Health Promotion Office Health and Welfare Department.
  • Watari H; Cytology Center, Public Interest Foundation Hokkaido Cancer Society.
  • Tamakoshi A; General Incorporated Association PCAF.
Nihon Koshu Eisei Zasshi ; 68(11): 719-727, 2021 Dec 04.
Article in Japanese | MEDLINE | ID: covidwho-1554772
ABSTRACT
Objectives We investigated the participation and detection rates of cervical lesions in cervical screening non-attenders offered HPV (human papillomavirus) self-sampling with cytology triage.Methods From 2016 to 2018, HPV self-sampling was routinely offered as an option, along with cytology, to all non-attenders in Ebetsu City, Japan. The primary endpoints were ≥CIN2 and ≥CIN3 detection rates, and secondary endpoints were abnormal cytology rates and follow-up compliance.Results Overall, recall invitations were mailed to 6,116 non-attenders, with a response rate of 15.9% (cytology 6.5%, HPV testing 9.4%). Of the responders to undergo HPV self-sampling, 11.7% had a positive result and were referred to cytology triage. Moreover, ≥CIN2 and ≥CIN3 detection rates were 1.7% and 0.9%, respectively, in the HPV self-sampling group, and 1.0% and 0.8%, respectively, in the cytology group, showing no statistically significant differences. In those who underwent cytology triage following an HPV positive test, ≥CIN2 and ≥CIN3 detection rates were 23.8% and 11.9%, respectively, which was significantly higher than those who only underwent cytology alone.Conclusion HPV self-sampling followed by cytology triage is highly effective at detecting high grade disease in non-attenders. Thus, multi-municipality-based studies to standardize processes involving this method are warranted. Furthermore, HPV self-sampling could be a promising method for inviting non-attenders who have difficulty undergoing cervical screening in the COVID-19 pandemic era.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections / COVID-19 Type of study: Cohort study / Diagnostic study / Prognostic study Limits: Female / Humans Language: Japanese Journal: Nihon Koshu Eisei Zasshi Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections / COVID-19 Type of study: Cohort study / Diagnostic study / Prognostic study Limits: Female / Humans Language: Japanese Journal: Nihon Koshu Eisei Zasshi Year: 2021 Document Type: Article