Your browser doesn't support javascript.
Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles.
Stinson, Jordan A; Boopathy, Archana V; Cieslewicz, Brian M; Zhang, Yichen; Hartman, Nickolas W; Miller, David P; Dirckx, Matthew; Hurst, Brett L; Tarbet, E Bart; Kluge, Jonathan A; Kosuda, Kathryn M.
  • Stinson JA; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Boopathy AV; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Cieslewicz BM; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Zhang Y; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Hartman NW; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Miller DP; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Dirckx M; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Hurst BL; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
  • Tarbet EB; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322, USA.
  • Kluge JA; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA.
  • Kosuda KM; Vaxess Technologies, Inc., 790 Memorial Drive, Suite 200, Cambridge, MA 02139, USA. Electronic address: kathryn@vaxess.com.
Vaccine ; 39(38): 5410-5421, 2021 09 07.
Article in English | MEDLINE | ID: covidwho-1351060
ABSTRACT
Traditional bolus vaccine administration leads to rapid clearance of vaccine from lymphoid tissue. However, there is increasing evidence suggesting that the kinetics of antigen delivery can impact immune responses to vaccines, particularly when tailored to mimic natural infections. Here, we present the specific enhancements sustained release immunization confers to seasonal influenza vaccine, including the magnitude, durability, and breadth of humoral responses. To achieve sustained vaccine delivery kinetics, we have developed a microneedle array patch (MIMIX), with silk fibroin-formulated vaccine tips designed to embed in the dermis after a short application to the skin and release antigen over 1-2 weeks, mimicking the time course of a natural influenza infection. In a preclinical murine model, a single influenza vaccine administration via MIMIX led to faster seroconversion, response-equivalence to prime-boost bolus immunization, higher HAI titers against drifted influenza strains, and improved protective efficacy upon lethal influenza challenge when compared with intramuscular injection. These results highlight infection mimicry, achieved through sustained release silk microneedles, as a powerful approach to improve existing seasonal influenza vaccines, while also suggesting the broader potential of this platform technology to enable more efficacious next-generation vaccines and vaccine combinations.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Vaccine Year: 2021 Document Type: Article Affiliation country: J.vaccine.2021.07.064

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Vaccine Year: 2021 Document Type: Article Affiliation country: J.vaccine.2021.07.064