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Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and Its Major Herbs.
Zhong, Linda Li Dan; Lam, Wai Ching; Yang, Wei; Chan, Kam Wa; Sze, Stephen Cho Wing; Miao, Jiangxia; Yung, Ken Kin Lam; Bian, Zhaoxiang; Wong, Vivian Taam.
  • Zhong LLD; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Lam WC; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Yang W; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Chan KW; Department of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Sze SCW; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Miao J; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, HKSAR 999077, P. R. China.
  • Yung KKL; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Bian Z; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region 999077, P. R. China.
  • Wong VT; School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region 999077, P. R. China.
Am J Chin Med ; 48(5): 1051-1071, 2020.
Article in English | MEDLINE | ID: covidwho-1352581
ABSTRACT
COVID-19 has been declared a pandemic by WHO on March 11, 2020. No specific treatment and vaccine with documented safety and efficacy for the disease have been established. Hence it is of utmost importance to identify more therapeutics such as Chinese medicine formulae to meet the urgent need. Qing Fei Pai Du Tang (QFPDT), a Chinese medicine formula consisting of 21 herbs from five classical formulae has been reported to be efficacious on COVID-19 in 10 provinces in mainland China. QFPDT could prevent the progression from mild cases and shorten the average duration of symptoms and hospital stay. It has been recommended in the 6th and 7th versions of Clinical Practice Guideline on COVID-19 in China. The basic scientific studies, supported by network pharmacology, on the possible therapeutic targets of QFPDT and its constituent herbs including Ephedra sinica, Bupleurum chinense, Pogostemon cablin, Cinnamomum cassia, Scutellaria baicalensis were reviewed. The anti-oxidation, immuno-modulation and antiviral mechanisms through different pathways were collated. Two clusters of actions identified were cytokine storm prevention and angiotensin converting enzyme 2 (ACE2) receptor binding regulation. The multi-target mechanisms of QFPDT for treating viral infection in general and COVID-19 in particular were validated. While large scale clinical studies on QFPDT are being conducted in China, one should use real world data for exploration of integrative treatment with inclusion of pharmacokinetic, pharmacodynamic and herb-drug interaction studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Drugs, Chinese Herbal / Coronavirus Infections Type of study: Prognostic study Topics: Traditional medicine / Vaccines Limits: Animals / Humans Country/Region as subject: Asia Language: English Journal: Am J Chin Med Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Drugs, Chinese Herbal / Coronavirus Infections Type of study: Prognostic study Topics: Traditional medicine / Vaccines Limits: Animals / Humans Country/Region as subject: Asia Language: English Journal: Am J Chin Med Year: 2020 Document Type: Article