COVID-19 and iron metabolism: traditional review
Turkiye Klinikleri tip Bilimleri Dergisi
; 41(2):176-188, 2021.
Article
in English
| CAB Abstracts | ID: covidwho-1352898
ABSTRACT
Viruses invade cells to reproduce, and they require an iron-filled cell for efficient reproduction. Together with other viruses, the coronavirus disease-2019 (COVID-19) virus can alter the expression of proteins involved in iron homeostasis. For example, in COVID-19 patients, an increase in pro-inflammatory cytokines such as interleukin-6 may stimulate the synthesis of hepcidin, the regulatory hormone of iron metabolism, thereby suppressing ferroportin-mediated cellular iron export. Increased serum levels of ferritin in COVID-19 virus infection is associated with a poor prognosis and may be partly due to the virus itself. Some viruses selectively infect iron acceptor cells (e.g. macrophages) by binding to transferrin receptor 1 during cell entry. Moreover, human airway secretions in the major route of entry of COVID-19 include transferrin and lactoferrin, and this glycoproteins can bind iron and maintain a chemically inert form. Understanding how iron metabolism and viral infection interact in the COVID-19 outbreak may suggest new ways to control the disease.
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
English
Journal:
Turkiye Klinikleri tip Bilimleri Dergisi
Year:
2021
Document Type:
Article
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