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Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors.
Kunze, Katie L; Johnson, Patrick W; van Helmond, Noud; Senefeld, Jonathon W; Petersen, Molly M; Klassen, Stephen A; Wiggins, Chad C; Klompas, Allan M; Bruno, Katelyn A; Mills, John R; Theel, Elitza S; Buras, Matthew R; Golafshar, Michael A; Sexton, Matthew A; Diaz Soto, Juan C; Baker, Sarah E; Shepherd, John R A; Verdun, Nicole C; Marks, Peter; Paneth, Nigel S; Fairweather, DeLisa; Wright, R Scott; van Buskirk, Camille M; Winters, Jeffrey L; Stubbs, James R; Senese, Katherine A; Pletsch, Michaela C; Buchholtz, Zachary A; Rea, Robert F; Herasevich, Vitaly; Whelan, Emily R; Clayburn, Andrew J; Larson, Kathryn F; Ripoll, Juan G; Andersen, Kylie J; Lesser, Elizabeth R; Vogt, Matthew N P; Dennis, Joshua J; Regimbal, Riley J; Bauer, Philippe R; Blair, Janis E; Casadevall, Arturo; Carter, Rickey E; Joyner, Michael J.
  • Kunze KL; Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ, USA.
  • Johnson PW; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
  • van Helmond N; Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ, USA.
  • Senefeld JW; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Petersen MM; Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ, USA.
  • Klassen SA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Wiggins CC; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Klompas AM; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Bruno KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
  • Mills JR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Theel ES; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Buras MR; Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ, USA.
  • Golafshar MA; Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ, USA.
  • Sexton MA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Diaz Soto JC; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Baker SE; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Shepherd JRA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Verdun NC; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Marks P; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Paneth NS; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
  • Fairweather D; Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
  • Wright RS; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
  • van Buskirk CM; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Winters JL; Human Research Protection Program, Mayo Clinic, Rochester, MN, USA.
  • Stubbs JR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Senese KA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Pletsch MC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Buchholtz ZA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Rea RF; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Herasevich V; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Whelan ER; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Clayburn AJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Larson KF; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
  • Ripoll JG; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Andersen KJ; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
  • Lesser ER; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Vogt MNP; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Dennis JJ; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
  • Regimbal RJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Bauer PR; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Blair JE; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Casadevall A; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
  • Carter RE; Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ, USA.
  • Joyner MJ; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Nat Commun ; 12(1): 4864, 2021 08 11.
Article in English | MEDLINE | ID: covidwho-1354101
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists as locally evolving variants suggests that immunological differences may impact the effectiveness of antibody-based treatments such as convalescent plasma and vaccines. Considering that near-sourced convalescent plasma likely reflects the antigenic composition of local viral strains, we hypothesize that convalescent plasma has a higher efficacy, as defined by death within 30 days of transfusion, when the convalescent plasma donor and treated patient were in close geographic proximity. Results of a series of modeling techniques applied to approximately 28,000 patients from the Expanded Access to Convalescent Plasma program (ClinicalTrials.gov number NCT04338360) support this hypothesis. This work has implications for the interpretation of clinical studies, the ability to develop effective COVID-19 treatments, and, potentially, for the effectiveness of COVID-19 vaccines as additional locally-evolving variants continue to emerge.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-25113-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-25113-5