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Opportunities, controversies, and challenges of extracorporeal hemoadsorption with CytoSorb during ECMO.
Napp, L Christian; Lebreton, Guillaume; De Somer, Filip; Supady, Alexander; Pappalardo, Federico.
  • Napp LC; Cardiac Arrest Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Lebreton G; Department of Cardiac and Thoracic Surgery, Cardiology Institute, La Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University Medical School, Paris, France.
  • De Somer F; Heart Centre 5K12, University Hospital Ghent, Ghent, Belgium.
  • Supady A; Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Pappalardo F; Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany.
Artif Organs ; 45(10): 1240-1249, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1354462
ABSTRACT
Extracorporeal membrane oxygenation (ECMO) is frequently used in many centers around the globe for various indications. However, prognosis is often poor even with all supportive therapies, and in many cases, clinical deterioration is associated with inflammation. Hemoadsorption with CytoSorb is a novel approach to limit the inflammatory response, and the device can be safely and easily installed into ECMO circuits. CytoSorb has been used more than 130.000 times to date, but because randomized controlled trials are largely lacking, there is substantial debate on its use. Here, experts from critical care medicine, cardiology, cardiac surgery, and perfusion technology discuss the pros and cons of this novel therapy and outline the future aspects for its clinical application and research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracorporeal Membrane Oxygenation / Hemofiltration Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Artif Organs Year: 2021 Document Type: Article Affiliation country: Aor.14025

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracorporeal Membrane Oxygenation / Hemofiltration Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Artif Organs Year: 2021 Document Type: Article Affiliation country: Aor.14025