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COVID-19-related diffuse leukoencephalopathy with microbleeds and persistent coma: a case report with good clinical outcome.
Witvoet, Elbert Hans; Jiang, Feng Yan; Laumans, Willemijn; de Bruijn, Sebastiaan Franciscus Titus Maria.
  • Witvoet EH; Department of Neurology, Haga Hospital, Den Haag, The Netherlands elbertwitvoet@gmail.com.
  • Jiang FY; Department of Radiology, Haga Hospital, Den Haag, The Netherlands.
  • Laumans W; Department of Intensive Care Medicine, Haga Hospital, Den Haag, The Netherlands.
  • de Bruijn SFTM; Department of Neurology, Haga Hospital, Den Haag, The Netherlands.
BMJ Case Rep ; 14(8)2021 Aug 11.
Article in English | MEDLINE | ID: covidwho-1354558
ABSTRACT
A 60-year-old patient presented with respiratory distress, after recently being tested COVID-19 positive and was mechanically ventilated for 15 days. After cessation of sedation, he remained in deep comatose state, without any reaction on pain stimuli (Glasgow Coma Score 3). MRI of the brain showed diffuse leukoencephalopathy and multiple (>50) microbleeds. Diffuse COVID-19-associated leukoencephalopathy with microhaemorrhages is associated with a poor prognosis. However, 3 months later, our patient showed a remarkable recovery and was able to walk independently. This case report shows COVID-related leukoencephalopathy and intracerebral microbleeds, even with persistent comatose state, may have a favourable clinical outcome and prolonged treatment should be considered in individual cases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukoencephalopathies / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-242504

Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukoencephalopathies / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-242504