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A History of Cerebrovascular Disease Is Independently Associated with Increased Morbidity and Mortality in Patients with COVID-19: A Cohort Study of 369,563 COVID-19 Cases in the USA.
Nia, Anna M; Srinivasan, Visish M; Hayworth, Miranda K; Lall, Rishi R; Kan, Peter.
  • Nia AM; Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA, annamnia@gmail.com.
  • Srinivasan VM; Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.
  • Hayworth MK; Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
  • Lall RR; Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
  • Kan P; Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
Cerebrovasc Dis ; 51(1): 20-28, 2022.
Article in English | MEDLINE | ID: covidwho-1354618
ABSTRACT

OBJECTIVES:

We set out to evaluate the risk for severe coronavirus disease 2019 (COVID-19) infection and subsequent cerebrovascular disease (CVD) in the population with a prior diagnosis of CVD within the past 10 years.

METHODS:

We utilized the TriNetX Analytics Network to query 369,563 CO-VID-19 cases up to December 30, 2020. We created 8 cohorts of patients with COVID-19 diagnosis based on a previous diagnosis of CVD. We measured the odds ratios, relative risks, risk differences for hospitalizations, ICU/critical care services, intubation, mortality, and CVD recurrence within 90 days of COVID-19 diagnosis, compared to a propensity-matched cohort with no prior history of CVD within 90 days of COVID-19 diagnosis.

RESULTS:

369,563 patients had a confirmed diagnosis of COVID-19 with a subset of 22,497 (6.09%) patients with a prior diagnosis of CVD within 10 years. All cohorts with a CVD diagnosis had an increased risk of hospitalization, critical care services, and mortality within 90 days of COVID-19 diagnosis. Additionally, the data demonstrate that any history of CVD is associated with significantly increased odds of subsequent CVD post-COVID-19 compared to a matched control.

CONCLUSIONS:

CVD, a known complication of CO-VID-19, is more frequent in patients with a prior history of CVD. Patients with any previous diagnosis of CVD are at higher risks of morbidity and mortality from COVID-19 infection. In patients admitted to the ED due to COVID-19 symptoms, these risk factors should be promptly identified as delayed or missed risk stratification and could lead to an ineffective and untimely diagnosis of subsequent CVD, which would lead to protracted hospitalization and poor prognosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Disorders / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Disorders / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2022 Document Type: Article