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HLA Does Not Impact on Short-Medium-Term Antibody Response to Preventive Anti-SARS-Cov-2 Vaccine.
Ragone, Concetta; Meola, Serena; Fiorillo, Pasqualina C; Penta, Roberta; Auriemma, Laura; Tornesello, Maria Lina; Miscio, Leonardo; Cavalcanti, Ernesta; Botti, Gerardo; Buonaguro, Franco M; Bianchi, Attilio; Buonaguro, Luigi; Tagliamonte, Maria.
  • Ragone C; Innovative Immunological Models Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Meola S; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Fiorillo PC; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Penta R; Ba.S.C.O. Unit, Cellular Manipulation and Immunogenetics, Oncology Department, AORN Santobono-Pausilipon, Naples, Italy.
  • Auriemma L; Ba.S.C.O. Unit, Cellular Manipulation and Immunogenetics, Oncology Department, AORN Santobono-Pausilipon, Naples, Italy.
  • Tornesello ML; Molecular Biology and Viral Oncogenesis Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Miscio L; Medical Direction, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Cavalcanti E; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Botti G; Scientific Direction, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Buonaguro FM; Molecular Biology and Viral Oncogenesis Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Bianchi A; General Direction, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Buonaguro L; Innovative Immunological Models Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
  • Tagliamonte M; Innovative Immunological Models Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Naples, Italy.
Front Immunol ; 12: 734689, 2021.
Article in English | MEDLINE | ID: covidwho-1354868
ABSTRACT
The response to anti-SARS-Cov-2 preventive vaccine shows high interpersonal variability at short and medium term. One of the explanations might be the individual HLA allelic variants. Indeed, B cell response is stimulated and sustained by CD4+ T helper cells activated by antigens presented by HLA-class II alleles on antigen-presenting cells (APCs). The impact of the number of antigens binding to HLA class-II alleles on the antibody response to the COVID vaccine has been assessed in a cohort of 56 healthcare workers who received the full schedule of the Pfizer-BioNTech BNT162b2 vaccine. Such vaccine is based on the entire spike protein of the SARS-CoV-2. Ab titers have been evaluated 2 weeks after the first dose as well as 2 weeks and 4 months after the boosting dose. HLA-DRB1 and DBQ1 for each of the vaccinees have been assessed, and strong binders have been predicted. The analysis showed no significant correlation between the short-medium-term Ab titers and the number of strong binders (SB) for each individual. These results indicate that levels of Ab response to the spike glycoprotein is not dependent on HLA class II allele, suggesting an equivalent efficacy at global level of the currently used vaccines. Furthermore, the pattern of persistence in Ab titer does not correlate with specific alleles or with the number of SBs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HLA-D Antigens / COVID-19 Vaccines / SARS-CoV-2 / Antibodies, Viral Topics: Vaccines / Variants Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.734689

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HLA-D Antigens / COVID-19 Vaccines / SARS-CoV-2 / Antibodies, Viral Topics: Vaccines / Variants Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.734689