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The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.
Brotons, Pedro; Jordan, Iolanda; Bassat, Quique; Henares, Desiree; Fernandez de Sevilla, Mariona; Ajanovic, Sara; Redin, Alba; Fumado, Vicky; Baro, Barbara; Claverol, Joana; Varo, Rosauro; Cuadras, Daniel; Hecht, Jochen; Barrabeig, Irene; Garcia-Garcia, Juan Jose; Launes, Cristian; Muñoz-Almagro, Carmen.
  • Brotons P; Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Jordan I; Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, Sant Cugat, 08195 Barcelona, Spain.
  • Bassat Q; Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain.
  • Henares D; Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Fernandez de Sevilla M; Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain.
  • Ajanovic S; Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Redin A; Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain.
  • Fumado V; Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Baro B; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça 1929, Mozambique.
  • Claverol J; ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain.
  • Varo R; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
  • Cuadras D; Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Hecht J; Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain.
  • Barrabeig I; Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Garcia-Garcia JJ; Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain.
  • Launes C; Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Muñoz-Almagro C; ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain.
Viruses ; 13(8)2021 08 12.
Article in English | MEDLINE | ID: covidwho-1355050
ABSTRACT
We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Picornaviridae Infections / Enterovirus Infections / Coinfection / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Young adult Language: English Year: 2021 Document Type: Article Affiliation country: V13081598

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Picornaviridae Infections / Enterovirus Infections / Coinfection / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Young adult Language: English Year: 2021 Document Type: Article Affiliation country: V13081598