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Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses.
Luan, Haoming; Horng, Tiffany.
  • Luan H; School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China.
  • Horng T; School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China. Electronic address: tsyhorng@shanghaitech.edu.cn.
Curr Opin Immunol ; 73: 9-15, 2021 12.
Article in English | MEDLINE | ID: covidwho-1355579
ABSTRACT
During microbial infection, macrophages link recognition of microbial stimuli to the induction of Type I inflammatory responses. Such inflammatory responses coordinate host defense and pathogen elimination but induce significant tissue damage if sustained, so macrophages are initially activated to induce inflammatory responses but then shift to a tolerant state to suppress inflammatory responses. Macrophage tolerance is regulated by induction of negative regulators of TLR signaling, but its metabolic basis was not known. Here, we review recent studies that indicate that macrophage metabolism changes dynamically over the course of microbial exposure to influence a shift in the inflammatory response. In particular, an initial increase in oxidative metabolism boosts the induction of inflammatory responses, but is followed by a shutdown of oxidative metabolism that contributes to suppression of inflammatory responses. We propose a unifying model for how dynamic changes to oxidative metabolism influences regulation of macrophage inflammatory responses during microbial exposure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / Inflammation / Macrophages Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Curr Opin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.coi.2021.07.012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidative Stress / Inflammation / Macrophages Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Curr Opin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.coi.2021.07.012