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Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States.
McCormick, David W; Richardson, LaTonia Clay; Young, Paul R; Viens, Laura J; Gould, Carolyn V; Kimball, Anne; Pindyck, Talia; Rosenblum, Hannah G; Siegel, David A; Vu, Quan M; Komatsu, Ken; Venkat, Heather; Openshaw, John J; Kawasaki, Breanna; Siniscalchi, Alan J; Gumke, Megan; Leapley, Andrea; Tobin-D'Angelo, Melissa; Kauerauf, Judy; Reid, Heather; White, Kelly; Ahmed, Farah S; Richardson, Gillian; Hand, Julie; Kirkey, Kim; Larson, Linnea; Byers, Paul; Garcia, Ali; Ojo, Mojisola; Zamcheck, Ariela; Lash, Maura K; Lee, Ellen H; Reilly, Kathleen H; Wilson, Erica; de Fijter, Sietske; Naqvi, Ozair H; Harduar-Morano, Laurel; Burch, Anna-Kathryn; Lewis, Adele; Kolsin, Jonathan; Pont, Stephen J; Barbeau, Bree; Bixler, Danae; Reagan-Steiner, Sarah; Koumans, Emilia H.
  • McCormick DW; Coronavirus Disease 2019 Response Team yup1@cdc.gov.
  • Richardson LC; Epidemic Intelligence Service.
  • Young PR; Coronavirus Disease 2019 Response Team.
  • Viens LJ; Coronavirus Disease 2019 Response Team.
  • Gould CV; Coronavirus Disease 2019 Response Team.
  • Kimball A; Coronavirus Disease 2019 Response Team.
  • Pindyck T; Coronavirus Disease 2019 Response Team.
  • Rosenblum HG; Epidemic Intelligence Service.
  • Siegel DA; Coronavirus Disease 2019 Response Team.
  • Vu QM; Coronavirus Disease 2019 Response Team.
  • Komatsu K; Epidemic Intelligence Service.
  • Venkat H; Coronavirus Disease 2019 Response Team.
  • Openshaw JJ; Coronavirus Disease 2019 Response Team.
  • Kawasaki B; Arizona Department of Health Services, Phoenix, Arizona.
  • Siniscalchi AJ; Arizona Department of Health Services, Phoenix, Arizona.
  • Gumke M; Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Leapley A; California Department of Public Health, Sacramento, California.
  • Tobin-D'Angelo M; Colorado Department of Public Health and Environment, Denver, Colorado.
  • Kauerauf J; State of Connecticut Department of Public Health, Hartford, Connecticut.
  • Reid H; Florida Department of Health, Tallahassee, Florida.
  • White K; Florida Department of Health, Tallahassee, Florida.
  • Ahmed FS; Georgia Department of Public Health, Atlanta, Georgia.
  • Richardson G; Illinois Department of Public Health, Springfield, Illinois.
  • Hand J; Illinois Department of Public Health, Springfield, Illinois.
  • Kirkey K; Indiana Department of Health, Indianapolis, Indiana.
  • Larson L; Kansas Department of Health and Environment, Topeka, Kansas.
  • Byers P; Louisiana Department of Health, Baton Rouge, Louisiana.
  • Garcia A; Louisiana Department of Health, Baton Rouge, Louisiana.
  • Ojo M; Michigan Department of Health and Human Services, Lansing, Michigan.
  • Zamcheck A; Minnesota Department of Health, Saint Paul, Minnesota.
  • Lash MK; Mississippi State Department of Health, Jackson, Mississippi.
  • Lee EH; Nevada Department of Health and Human Services, Carson City, Nevada.
  • Reilly KH; New Jersey Department of Health, Trenton, New Jersey.
  • Wilson E; New York State Department of Health, Albany, New York.
  • de Fijter S; New York City Department of Health and Mental Hygiene, New York City, New York.
  • Naqvi OH; New York City Department of Health and Mental Hygiene, New York City, New York.
  • Harduar-Morano L; New York City Department of Health and Mental Hygiene, New York City, New York.
  • Burch AK; North Carolina Department of Health and Human Services, Raleigh, North Carolina.
  • Lewis A; Ohio Department of Health, Columbus, Ohio.
  • Kolsin J; Oklahoma State Department of Health, Oklahoma City, Oklahoma.
  • Pont SJ; Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Barbeau B; Pennsylvania Department of Health, Harrisburg, Pennsylvania.
  • Bixler D; South Carolina Department of Health and Environmental Control, Columbia, South Carolina.
  • Reagan-Steiner S; Tennessee Department of Health, Nashville, Tennessee.
  • Koumans EH; Texas Department of State Health Services, Austin, Texas.
Pediatrics ; 148(5)2021 11.
Article in English | MEDLINE | ID: covidwho-1357451
ABSTRACT

OBJECTIVES:

To describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated death.

METHODS:

We conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12 to July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records.

RESULTS:

We included 112 SARS-CoV-2-associated deaths from 25 participating jurisdictions. The median age was 17 years (IQR 8.5-19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least 1 underlying condition; obesity (42%), asthma (29%), and developmental disorders (22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (75%) and acute respiratory failure (82%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, sex, and race and/or ethnicity to decedents without MIS-C; 11 of 16 (69%) had at least 1 underlying condition.

CONCLUSIONS:

SARS-CoV-2-associated deaths among persons <21 years of age occurred predominantly among Black (non-Hispanic) and Hispanic persons, male patients, and older adolescents. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with coronavirus disease 2019 were more likely than those with MIS-C to have underlying medical conditions.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: North America Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: North America Language: English Year: 2021 Document Type: Article