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Nature and Dimensions of Systemic Hyperinflammation and its Attenuation by Convalescent Plasma in Severe COVID-19.
Bandopadhyay, Purbita; D'Rozario, Ranit; Lahiri, Abhishake; Sarif, Jafar; Ray, Yogiraj; Paul, Shekhar Ranjan; Roy, Rammohan; Maiti, Rajshekhar; Chaudhuri, Kausik; Bagchi, Saugata; Maiti, Ayan; Perwez, Mohammed Masoom; Sarkar, Biswanath Sharma; Roy, Devlina; Chakraborty, Rahul; Vasudevan, Janani Srinivasa; Sharma, Sachin; Biswas, Durba; Maiti, Chikam; Saha, Bibhuti; Bhattacharya, Prasun; Pandey, Rajesh; Chatterjee, Shilpak; Paul, Sandip; Ganguly, Dipyaman.
  • Bandopadhyay P; Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • D'Rozario R; Department of Immunohematology and Blood Transfusion, Medical College Hospital, Kolkata, India.
  • Lahiri A; Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Sarif J; Department of Immunohematology and Blood Transfusion, Medical College Hospital, Kolkata, India.
  • Ray Y; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
  • Paul SR; Department of Immunohematology and Blood Transfusion, Medical College Hospital, Kolkata, India.
  • Roy R; Translational Research Unit of Excellence, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Maiti R; Department of Immunohematology and Blood Transfusion, Medical College Hospital, Kolkata, India.
  • Chaudhuri K; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Bagchi S; Department of Medicine, Infectious Diseases and Beliaghata General Hospital, Kolkata, India.
  • Maiti A; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Perwez MM; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Sarkar BS; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Roy D; Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India.
  • Chakraborty R; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Vasudevan JS; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Sharma S; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Biswas D; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Maiti C; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Saha B; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Bhattacharya P; Division of Structural Biology and Bioinformatics, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.
  • Pandey R; Department of Pediatrics, Sagar Dutta Hospital and College of Medicine, Kolkata, India.
  • Chatterjee S; Department of Pediatrics, Sagar Dutta Hospital and College of Medicine, Kolkata, India.
  • Paul S; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, Delhi, India.
  • Ganguly D; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, Delhi, India.
J Infect Dis ; 224(4): 565-574, 2021 08 16.
Article in English | MEDLINE | ID: covidwho-1358458
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has led to significant morbidity and mortality. While most suffer from mild symptoms, some patients progress to severe disease with acute respiratory distress syndrome (ARDS) and associated systemic hyperinflammation.

METHODS:

First, to characterize key cytokines and their dynamics in this hyperinflammatory condition, we assessed abundance and correlative expression of a panel of 48 cytokines in patients progressing to ARDS as compared to patients with mild disease. Then, in an ongoing randomized controlled trial of convalescent plasma therapy (CPT), we analyzed rapid effects of CPT on the systemic cytokine dynamics as a correlate for the level of hypoxia experienced by the patients.

RESULTS:

We identified an anti-inflammatory role of CPT independent of its neutralizing antibody content.

CONCLUSIONS:

Neutralizing antibodies, as well as reductions in circulating interleukin-6 and interferon-γ-inducible protein 10, contributed to marked rapid reductions in hypoxia in response to CPT. CLINICAL TRIAL REGISTRY OF INDIA CTRI/2020/05/025209. http//www.ctri.nic.in/.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis