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Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
Peluso, Michael J; Munter, Sadie E; Lynch, Kara L; Yun, Cassandra; Torres, Leonel; Iyer, Nikita S; Donatelli, Joanna; Ryan, Lindsay; Deitchman, Amelia N; Deeks, Steven G; Rutishauser, Rachel L; Henrich, Timothy J.
  • Peluso MJ; Division of HIV, Infectious Disease and Global Medicine, University of California San Francisco, San Francisco, California, USA.
  • Munter SE; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Lynch KL; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Yun C; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Torres L; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Iyer NS; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Donatelli J; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Ryan L; Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Deitchman AN; Department of Clinical Pharmacology, University of California San Francisco, San Francisco, California, USA.
  • Deeks SG; Division of HIV, Infectious Disease and Global Medicine, University of California San Francisco, San Francisco, California, USA.
  • Rutishauser RL; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Henrich TJ; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
Open Forum Infect Dis ; 8(8): ofab393, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1358479
ABSTRACT
We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid