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Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Continuum (Minneap Minn) ; 27(4): 1051-1065, 2021 08 01.
Article in English | MEDLINE | ID: covidwho-1359094
ABSTRACT
PURPOSE OF REVIEW This article describes the spectrum of neurologic complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, their underlying pathology and pathogenic mechanisms, gaps in knowledge, and current therapeutic strategies. RECENT

FINDINGS:

COVID-19 is the clinical syndrome caused by the novel coronavirus SARS-CoV-2. It can affect the entire neuraxis, and presentations in the acute phase are variable, although anosmia is a common manifestation. Encephalopathy is common in patients who are hospitalized and is often associated with multiorgan involvement. Immune-mediated encephalitis is probably underrecognized; however, viral encephalitis is rare. Other manifestations include stroke, seizures, myelitis, and peripheral neuropathies, including Guillain-Barré syndrome, which sometimes has atypical manifestations. Treatment is symptomatic, and immunotherapies have been used successfully in some patients. Long-term complications include dysautonomia, exercise intolerance, malaise, sleep disturbances, cognitive impairment, and mood disorders.

SUMMARY:

Neurologic manifestations of COVID-19 may occur in the acute setting and may be independent of respiratory manifestations. Immune-mediated syndromes and cerebrovascular complications are common. Large populations of patients are expected to have long-term neurologic complications of COVID-19, many of which may emerge only after recovery from the acute illness.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Peripheral Nervous System Diseases / Stroke / COVID-19 / Nervous System Diseases Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Continuum (Minneap Minn) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peripheral Nervous System Diseases / Stroke / COVID-19 / Nervous System Diseases Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Continuum (Minneap Minn) Year: 2021 Document Type: Article