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Anti-SARS-CoV-2 IgG levels in relation to disease severity of COVID-19
Journal of Medical Virology ; 17:17, 2021.
Article in English | MEDLINE | ID: covidwho-1359798
ABSTRACT
The durability of infection-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity has crucial implications for reinfection and vaccine effectiveness. However, the relationship between coronavirus disease 2019 (COVID-19) severity and long-term anti-SARS-CoV-2 IgG antibody level is poorly understood. Here, we measured the longevity of SARS-CoV-2-specific IgG antibodies in survivors who had recovered from COVID-19 1 year previously. In a cohort of 473 survivors with varying disease severity (asymptomatic, mild, moderate, or severe), we observed a positive correlation between virus-specific IgG antibody titers and COVID-19 severity. In particular, the highest virus-specific IgG antibody titers were observed in patients with severe COVID-19. By contrast, 74.4% of recovered asymptomatic carriers had negative anti-SARS-CoV-2 IgG test results, while many others had very low virus-specific IgG antibody titers. Our results demonstrate that SARS-CoV-2-specific IgG persistence and titer depend on COVID-19 severity. This article is protected by copyright. All rights reserved.

Full text: Available Collection: Databases of international organizations Database: MEDLINE Document Type: Article Language: English Journal: Journal of Medical Virology Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: Databases of international organizations Database: MEDLINE Document Type: Article Language: English Journal: Journal of Medical Virology Clinical aspect: Etiology Year: 2021
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