Resveratrol supplementation reduces ACE2 expression in human adipose tissue.
Adipocyte
; 10(1): 408-411, 2021 12.
Article
in English
| MEDLINE | ID: covidwho-1360282
ABSTRACT
Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we investigated the effects of 30-days resveratrol supplementation on RAS components in AT and skeletal muscle in men with obesity in a placebo-controlled cross-over study. Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components. These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Adipose Tissue
/
Resveratrol
/
Angiotensin-Converting Enzyme 2
Type of study:
Experimental Studies
/
Randomized controlled trials
Topics:
Traditional medicine
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Adipocyte
Year:
2021
Document Type:
Article
Affiliation country:
21623945.2021.1965315
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