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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study.
Schroeder, Maria; Schaumburg, Berfin; Mueller, Zacharias; Parplys, Ann; Jarczak, Dominik; Roedl, Kevin; Nierhaus, Axel; de Heer, Geraldine; Grensemann, Joern; Schneider, Bettina; Stoll, Fabian; Bai, Tian; Jacobsen, Henning; Zickler, Martin; Stanelle-Bertram, Stephanie; Klaetschke, Kristin; Renné, Thomas; Meinhardt, Andreas; Aberle, Jens; Hiller, Jens; Peine, Sven; Kreienbrock, Lothar; Klingel, Karin; Kluge, Stefan; Gabriel, Guelsah.
  • Schroeder M; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schaumburg B; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Mueller Z; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Parplys A; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Jarczak D; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Roedl K; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Nierhaus A; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • de Heer G; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Grensemann J; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schneider B; Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Stoll F; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Bai T; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Jacobsen H; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Zickler M; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Stanelle-Bertram S; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Klaetschke K; Institute for Clinical and Laboratory Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Renné T; Institute for Clinical and Laboratory Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Meinhardt A; Institute of Anatomy and Cell Biology, Justus-Liebig University of Giessen, Giessen, Germany.
  • Aberle J; Department of Endocrinology, Diabetology, Obesity and Lipids, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hiller J; Institute for Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Peine S; Institute for Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kreienbrock L; Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Hannover, Germany.
  • Klingel K; Institute for Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany.
  • Kluge S; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Gabriel G; Department for Viral Zoonoses-One Health, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Emerg Microbes Infect ; 10(1): 1807-1818, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1360311
ABSTRACT
Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Testosterone / Estradiol / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article Affiliation country: 22221751.2021.1969869

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Testosterone / Estradiol / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article Affiliation country: 22221751.2021.1969869