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Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.
Haran, John P; Bradley, Evan; Zeamer, Abigail L; Cincotta, Lindsey; Salive, Marie-Claire; Dutta, Protiva; Mutaawe, Shafik; Anya, Otuwe; Meza-Segura, Mario; Moormann, Ann M; Ward, Doyle V; McCormick, Beth A; Bucci, Vanni.
  • Haran JP; Department of Emergency Medicine.
  • Bradley E; Department of Microbiology and Physiological Systems.
  • Zeamer AL; Program in Microbiome Dynamics, and.
  • Cincotta L; Department of Emergency Medicine.
  • Salive MC; Program in Microbiome Dynamics, and.
  • Dutta P; Department of Microbiology and Physiological Systems.
  • Mutaawe S; Program in Microbiome Dynamics, and.
  • Anya O; Department of Emergency Medicine.
  • Meza-Segura M; Department of Emergency Medicine.
  • Moormann AM; Department of Emergency Medicine.
  • Ward DV; Department of Emergency Medicine.
  • McCormick BA; Department of Emergency Medicine.
  • Bucci V; Department of Microbiology and Physiological Systems.
JCI Insight ; 6(20)2021 10 22.
Article in English | MEDLINE | ID: covidwho-1360585
ABSTRACT
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dysbiosis / Microbiota / COVID-19 / Inflammation Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dysbiosis / Microbiota / COVID-19 / Inflammation Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article