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Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
Cheng, Fang-Ju; Huynh, Thanh-Kieu; Yang, Chia-Shin; Hu, Dai-Wei; Shen, Yi-Cheng; Tu, Chih-Yen; Wu, Yang-Chang; Tang, Chih-Hsin; Huang, Wei-Chien; Chen, Yeh; Ho, Chien-Yi.
  • Cheng FJ; Drug Development Center, China Medical University, Taichung 404, Taiwan.
  • Huynh TK; Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan.
  • Yang CS; Institute of New Drug Development, China Medical University, Taichung 404, Taiwan.
  • Hu DW; Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan.
  • Shen YC; Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan.
  • Tu CY; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung 404, Taiwan.
  • Wu YC; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung 404, Taiwan.
  • Tang CH; School of Medicine, China Medical University, Taichung 404, Taiwan.
  • Huang WC; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
  • Chen Y; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
  • Ho CY; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 404, Taiwan.
Nutrients ; 13(8)2021 Aug 16.
Article in English | MEDLINE | ID: covidwho-1360797
ABSTRACT
Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of HD with high bioavailability. Through the docking simulation, HD and HT have shown their potential to bind to two cellular proteins transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2), which are required for the cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our results further found that HT and HD suppressed the infection of VeroE6 cells using lentiviral-based pseudo-particles with wild types and variants of SARS-CoV-2 with spike (S) proteins, by blocking the interaction between the S protein and cellular receptor ACE2 and reducing ACE2 and TMPRSS2 expression. In summary, hesperidin is a potential TMPRSS2 inhibitor for the reduction of the SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment / Hesperidin Topics: Variants Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Nu13082800

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment / Hesperidin Topics: Variants Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Nu13082800