Your browser doesn't support javascript.
Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors.
Tan, Chee-Wah; Chia, Wan-Ni; Young, Barnaby E; Zhu, Feng; Lim, Beng-Lee; Sia, Wan-Rong; Thein, Tun-Linn; Chen, Mark I-C; Leo, Yee-Sin; Lye, David C; Wang, Lin-Fa.
  • Tan CW; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Chia WN; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Young BE; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Zhu F; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Lim BL; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Sia WR; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Thein TL; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Chen MI; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Leo YS; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Lye DC; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
  • Wang LF; From the Programme in Emerging Infectious Diseases, Duke-NUS (National University of Singapore) Medical School (C.-W.T., W.-N.C., F.Z., B.-L.L., W.-R.S., L.-F.W.), the National Centre for Infectious Diseases (B.E.Y., T.-L.T., M.I.-C.C., Y.-S.L., D.C.L.), Tan Tock Seng Hospital (B.E.Y., M.I.-C.C., Y.
N Engl J Med ; 385(15): 1401-1406, 2021 10 07.
Article in English | MEDLINE | ID: covidwho-1361670
ABSTRACT
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines. A vaccine that could prevent infection caused by known and future variants of concern as well as infection with pre-emergent sarbecoviruses (i.e., those with potential to cause disease in humans in the future) would be ideal. Here we provide data showing that potent cross-clade pan-sarbecovirus neutralizing antibodies are induced in survivors of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) infection who have been immunized with the BNT162b2 messenger RNA (mRNA) vaccine. The antibodies are high-level and broad-spectrum, capable of neutralizing not only known variants of concern but also sarbecoviruses that have been identified in bats and pangolins and that have the potential to cause human infection. These findings show the feasibility of a pan-sarbecovirus vaccine strategy. (Funded by the Singapore National Research Foundation and National Medical Research Council.).
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Broadly Neutralizing Antibodies / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: N Engl J Med Year: 2021 Document Type: Article

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Broadly Neutralizing Antibodies / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: N Engl J Med Year: 2021 Document Type: Article