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Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019.
Bainbridge, Emma D; Hsue, Priscilla Y; Esensten, Jonathan H; Lynch, Kara L; Hendrickson, Carolyn M; Doernberg, Sarah B; Fung, Monica; Chin-Hong, Peter; Di Germanio, Clara; Norris, Philip J; Simmons, Graham; Glidden, David V; Luetkemeyer, Anne F.
  • Bainbridge ED; Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
  • Hsue PY; Division of Cardiology, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, California, USA.
  • Esensten JH; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Lynch KL; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Hendrickson CM; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, California, USA.
  • Doernberg SB; Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
  • Fung M; Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
  • Chin-Hong P; Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
  • Di Germanio C; Vitalant Research Institute, San Francisco, California, USA.
  • Norris PJ; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Simmons G; Vitalant Research Institute, San Francisco, California, USA.
  • Glidden DV; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Luetkemeyer AF; Vitalant Research Institute, San Francisco, California, USA.
Open Forum Infect Dis ; 8(8): ofab385, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1361798
ABSTRACT
We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid