Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development.
Int J Nanomedicine
; 16: 5411-5435, 2021.
Article
in English
| MEDLINE | ID: covidwho-1362163
ABSTRACT
Advances in nanobiotechnology have allowed the utilization of nanotechnology through nanovaccines. Nanovaccines are powerful tools for enhancing the immunogenicity of a specific antigen and exhibit advantages over other adjuvant approaches, with features such as expanded stability, prolonged release, decreased immunotoxicity, and immunogenic selectivity. We introduce recent advances in carbon nanotubes (CNTs) to induce either a carrier effect as a nanoplatform or an immunostimulatory effect. Several studies of CNT-based nanovaccines revealed that due to the ability of CNTs to carry immunogenic molecules, they can act as nonclassical vaccines, a quality not possessed by vaccines with traditional formulations. Therefore, adapting and modifying the physicochemical properties of CNTs for use in vaccines may additionally enhance their efficacy in inducing a T cell-based immune response. Accordingly, the purpose of this study is to renew and awaken interest in and knowledge of the safe use of CNTs as adjuvants and carriers in vaccines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Nanotubes, Carbon
Topics:
Vaccines
Language:
English
Journal:
Int J Nanomedicine
Year:
2021
Document Type:
Article
Affiliation country:
IJN.S314308
Similar
MEDLINE
...
LILACS
LIS