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Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID-19 neuropathy patients.
Manganotti, Paolo; Bellavita, Giulia; Tommasini, Valentina; D Acunto, Laura; Fabris, Martina; Cecotti, Laura; Furlanis, Giovanni; Sartori, Arianna; Bonzi, Lucia; Buoite Stella, Alex; Pesavento, Valentina.
  • Manganotti P; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • Bellavita G; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • Tommasini V; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • D Acunto L; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • Fabris M; Lab. Malattie Autoimmuni, SOC Istituto di Patologia Clinica, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
  • Cecotti L; Rehabilitation Unit of Severe cerebrovascular lesion, Gervasutta Hospital, Udine, Italy.
  • Furlanis G; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • Sartori A; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • Bonzi L; Rehabilitation Unit, Maggiore City Hospital Department of Medicine, Surgery and Health Sciences, ASUGI, Trieste, Italy.
  • Buoite Stella A; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
  • Pesavento V; Rehabilitation Unit, Maggiore City Hospital Department of Medicine, Surgery and Health Sciences, ASUGI, Trieste, Italy.
J Med Virol ; 93(9): 5432-5437, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1363681
Semantic information from SemMedBD (by NLM)
1. Neuropathy PROCESS_OF Patients
Subject
Neuropathy
Predicate
PROCESS_OF
Object
Patients
2. Polyradiculoneuritis PROCESS_OF Patients
Subject
Polyradiculoneuritis
Predicate
PROCESS_OF
Object
Patients
3. immunoglobulin TREATS C0235031
Subject
immunoglobulin
Predicate
TREATS
Object
C0235031
4. Cerebrospinal Fluid LOCATION_OF interleukin-6
Subject
Cerebrospinal Fluid
Predicate
LOCATION_OF
Object
interleukin-6
5. Serum LOCATION_OF interleukin-6
Subject
Serum
Predicate
LOCATION_OF
Object
interleukin-6
6. Serum LOCATION_OF interleukin-8
Subject
Serum
Predicate
LOCATION_OF
Object
interleukin-8
7. Cerebrospinal Fluid LOCATION_OF interleukin-8
Subject
Cerebrospinal Fluid
Predicate
LOCATION_OF
Object
interleukin-8
8. Inflammatory Response COEXISTS_WITH Complication
Subject
Inflammatory Response
Predicate
COEXISTS_WITH
Object
Complication
9. interleukin-6 ASSOCIATED_WITH COVID-19
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
COVID-19
10. interleukin-8 ASSOCIATED_WITH COVID-19
Subject
interleukin-8
Predicate
ASSOCIATED_WITH
Object
COVID-19
11. Neuropathy PROCESS_OF Patients
Subject
Neuropathy
Predicate
PROCESS_OF
Object
Patients
12. Polyradiculoneuritis PROCESS_OF Patients
Subject
Polyradiculoneuritis
Predicate
PROCESS_OF
Object
Patients
13. immunoglobulins, intravenous TREATS Neurologic Symptoms
Subject
immunoglobulins, intravenous
Predicate
TREATS
Object
Neurologic Symptoms
14. Cerebrospinal Fluid LOCATION_OF interleukin-6
Subject
Cerebrospinal Fluid
Predicate
LOCATION_OF
Object
interleukin-6
15. Serum LOCATION_OF interleukin-6
Subject
Serum
Predicate
LOCATION_OF
Object
interleukin-6
16. Serum LOCATION_OF interleukin-8
Subject
Serum
Predicate
LOCATION_OF
Object
interleukin-8
17. Cerebrospinal Fluid LOCATION_OF interleukin-8
Subject
Cerebrospinal Fluid
Predicate
LOCATION_OF
Object
interleukin-8
18. Inflammatory Response COEXISTS_WITH Complication
Subject
Inflammatory Response
Predicate
COEXISTS_WITH
Object
Complication
19. interleukin-6 ASSOCIATED_WITH COVID-19
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
COVID-19
20. interleukin-8 ASSOCIATED_WITH COVID-19
Subject
interleukin-8
Predicate
ASSOCIATED_WITH
Object
COVID-19
ABSTRACT
This case series describes three patients affected by severe acute respiratory syndrome coronavirus 2, who developed polyradiculoneuritis as a probable neurological complication of coronavirus disease 2019 (COVID-19). A diagnosis of Guillain Barré syndrome was made on the basis of clinical symptoms, cerebrospinal fluid analysis, and electroneurography. In all of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4 gr/kg for 5 days), which resulted in the improvement of neurological symptoms. Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases, a significant decrease in amplitude of compound motor action potential cMAP. Due to the potential role of inflammation on symptoms development and prognosis, interleukin-6 (IL-6) and IL-8 levels were measured in serum and cerebrospinal fluid during the acute phase, while only serum was tested after recovery. Both IL-6 and IL-8 were found increased during the acute phase, both in the serum and cerebrospinal fluid, whereas 4 months after admission (at complete recovery), only IL-8 remained elevated in the serum. These results confirm the inflammatory response that might be linked to peripheral nervous system complications and encourage the use of IL-6 and IL-8 as prognostic biomarkers in COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Interleukin-8 / Interleukin-6 / Guillain-Barre Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27061

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Interleukin-8 / Interleukin-6 / Guillain-Barre Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27061