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MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients.
D Avila-Mesquita, Carolina; Couto, Ariel E S; Campos, Ligia C B; Vasconcelos, Tauana F; Michelon-Barbosa, Jessyca; Corsi, Carlos A C; Mestriner, Fabiola; Petroski-Moraes, Bruno C; Garbellini-Diab, Maria J; Couto, Daniel M S; Jordani, Maria C; Ferro, Denise; Sbragia, Lourenço; Joviliano, Edwaldo E; Evora, Paulo R; Carvalho Santana, Rodrigo de; Martins-Filho, Olindo Assis; Polonis, Katarzyna; Menegueti, Mayra G; Ribeiro, Mauricio S; Auxiliadora-Martins, Maria; Becari, Christiane.
  • D Avila-Mesquita C; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Couto AES; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Campos LCB; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Vasconcelos TF; Division of Intensive Care, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Michelon-Barbosa J; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Corsi CAC; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Mestriner F; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Petroski-Moraes BC; Division of Intensive Care, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Garbellini-Diab MJ; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Couto DMS; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Jordani MC; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Ferro D; Division of Cardiac Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Sbragia L; Division of Pediatrics Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Joviliano EE; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Evora PR; Division of Cardiac Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Carvalho Santana R; Division of Infectious Diseases, Department of Clinical Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Martins-Filho OA; René Rachou Institute, Oswaldo Cruz Foundation, FIOCRUZ-Minas, Brazil.
  • Polonis K; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Menegueti MG; Ribeirão Preto Nurse Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Ribeiro MS; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Auxiliadora-Martins M; Division of Intensive Care, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Becari C; Division of Vascular and Endovascular Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Electronic address: cbecari@usp.br.
Biomed Pharmacother ; 142: 112067, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1363885
ABSTRACT
Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Matrix Metalloproteinase 2 / Matrix Metalloproteinase 9 / COVID-19 / Hypertension / Intensive Care Units Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: Biomed Pharmacother Year: 2021 Document Type: Article Affiliation country: J.biopha.2021.112067

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Matrix Metalloproteinase 2 / Matrix Metalloproteinase 9 / COVID-19 / Hypertension / Intensive Care Units Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: Biomed Pharmacother Year: 2021 Document Type: Article Affiliation country: J.biopha.2021.112067