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Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.
Wylezich, Claudia; Schaller, Tina; Claus, Rainer; Hirschbühl, Klaus; Märkl, Bruno; Kling, Elisabeth; Spring, Oliver; Höper, Dirk; Schlegel, Jürgen; Beer, Martin; Dintner, Sebastian.
  • Wylezich C; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany. Electronic address: claudia.wylezich@fli.de.
  • Schaller T; Department of General Pathology and Molecular Diagnostics, University of Augsburg, Augsburg, Germany.
  • Claus R; Department of Hematology and Oncology, University of Augsburg, Augsburg, Germany.
  • Hirschbühl K; Department of Hematology and Oncology, University of Augsburg, Augsburg, Germany.
  • Märkl B; Department of General Pathology and Molecular Diagnostics, University of Augsburg, Augsburg, Germany.
  • Kling E; Department of Microbiology, University of Augsburg, Augsburg, Germany.
  • Spring O; Anesthesiology and Operative Intensive Care Medicine,University of Augsburg, Augsburg, Germany.
  • Höper D; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.
  • Schlegel J; Department of Neuropathology, School of Medicine, Institute of Pathology, Technical University Munich, Munich, Germany.
  • Beer M; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.
  • Dintner S; Department of General Pathology and Molecular Diagnostics, University of Augsburg, Augsburg, Germany.
Diagn Microbiol Infect Dis ; 101(4): 115520, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1363963
ABSTRACT
Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory System / Adaptation, Physiological / Whole Genome Sequencing / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study Limits: Humans Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory System / Adaptation, Physiological / Whole Genome Sequencing / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study Limits: Humans Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article