Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.
Diagn Microbiol Infect Dis
; 101(4): 115520, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1363963
ABSTRACT
Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory System
/
Adaptation, Physiological
/
Whole Genome Sequencing
/
SARS-CoV-2
/
COVID-19
Type of study:
Case report
/
Observational study
Limits:
Humans
Language:
English
Journal:
Diagn Microbiol Infect Dis
Year:
2021
Document Type:
Article
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