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Association Between Accelerometer-Assessed Physical Activity and Severity of COVID-19 in UK Biobank.
Rowlands, Alex V; Dempsey, Paddy C; Gillies, Clare; Kloecker, David E; Razieh, Cameron; Chudasama, Yogini; Islam, Nazrul; Zaccardi, Francesco; Lawson, Claire; Norris, Tom; Davies, Melanie J; Khunti, Kamlesh; Yates, Tom.
  • Rowlands AV; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Dempsey PC; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, United Kingdom.
  • Gillies C; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Kloecker DE; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, United Kingdom.
  • Razieh C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Chudasama Y; Physical Activity and Behavioural Epidemiology Laboratories, Baker Heart and Diabetes Institute, Melbourne, Australia.
  • Islam N; Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Zaccardi F; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Lawson C; Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Norris T; St George's University of London, Tooting, London, United Kingdom.
  • Davies MJ; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Khunti K; Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, United Kingdom.
  • Yates T; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), University Hospitals of Leicester NHS Trust and the University of Leicester, Leicester, United Kingdom.
Mayo Clin Proc Innov Qual Outcomes ; 5(6): 997-1007, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1364354
ABSTRACT

Objective:

To quantify the association between accelerometer-assessed physical activity and coronavirus disease 2019 (COVID-19) outcomes.

Methods:

Data from 82,253 UK Biobank participants with accelerometer data (measured 2013-2015), complete covariate data, and linked COVID-19 data from March 16, 2020, to March 16, 2021, were included. Two outcomes were investigated severe COVID-19 (positive test result from in-hospital setting or COVID-19 as primary cause of death) and nonsevere COVID-19 (positive test result from community setting). Logistic regressions were used to assess associations with moderate to vigorous physical activity (MVPA), total activity, and intensity gradient. A higher intensity gradient indicates a higher proportion of vigorous activity.

Results:

Average MVPA was 48.1 (32.7) min/d. Physical activity was associated with lower odds of severe COVID-19 (adjusted odds ratio per standard deviation increase MVPA, 0.75 [95% CI, 0.67 to 0.85]; total, 0.83 [0.74 to 0.92]; intensity, 0.77 [0.70 to 0.86]), with stronger associations in women (MVPA, 0.63 [0.52 to 0.77]; total, 0.76 [0.64 to 0.90]; intensity, 0.63 [0.53 to 0.74]) than in men (MVPA, 0.84 [0.73 to 0.97]; total, 0.88 [0.77 to 1.01]; intensity, 0.88 [0.77 to 1.00]). In contrast, when mutually adjusted, total activity was associated with higher odds of a nonsevere infection (1.10 [1.04 to 1.16]), whereas the intensity gradient was associated with lower odds (0.91 [0.86 to 0.97]).

Conclusion:

Odds of severe COVID-19 were approximately 25% lower per standard deviation (∼30 min/d) MVPA. A greater proportion of vigorous activity was associated with lower odds of severe and nonsevere infections. The association between total activity and higher odds of a nonsevere infection may be through greater community engagement and thus more exposure to the virus. Results support calls for public health messaging highlighting the potential of MVPA for reducing the odds of severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Risk factors Language: English Journal: Mayo Clin Proc Innov Qual Outcomes Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Risk factors Language: English Journal: Mayo Clin Proc Innov Qual Outcomes Year: 2021
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