The Relationship Between Insulin Use And Increased Mortality In Patients With COVID-19 And Diabetes: A Meta-Analysis.
Endocr Res
; 47(1): 32-38, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1364665
ABSTRACT
PURPOSE:
The purpose of this study is to review observational studies on the effect of insulin use and mortality in patients with COVID-19 and diabetes.METHODS:
A systematic literature search was performed using the PubMed, Medline, EMBASE, and Cochrane Library databases. The meta-analysis was performed using a random effects model, and I2 was applied to evaluate heterogeneity. Sensitivity and subgroup analyses were also performed.RESULTS:
Overall, 1,338 patients over six studies were ultimately included. Insulin use was related to a higher risk of death in diabetic patients with COVID-19 compared to those who did not use insulin (odds ratio 2.59, 95% confidence interval 1.66-4.05; P < .0001; I2 57%).CONCLUSIONS:
This meta-analysis revealed a correlation between insulin usage and increased mortality in diabetic patients with COVID-19. These results showed that insulin requirement in patients with COVID-19 and diabetes might indicate a poor prognosis.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Endocr Res
Journal subject:
Endocrinology
Year:
2022
Document Type:
Article
Affiliation country:
07435800.2021.1967376
Similar
MEDLINE
...
LILACS
LIS