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The Relationship Between Insulin Use And Increased Mortality In Patients With COVID-19 And Diabetes: A Meta-Analysis.
Wang, Wanteng; Sun, Yu; Wang, Shuai; Sun, Yunbo.
  • Wang W; The Affiliated Hospital Of Qingdao University, Qingdao University, Qingdao, China.
  • Sun Y; The Affiliated Hospital Of Qingdao University, Qingdao University, Qingdao, China.
  • Wang S; The Affiliated Hospital Of Qingdao University, Qingdao University, Qingdao, China.
  • Sun Y; Department of Intensive Care Unit, The Affiliated Hospital of Qingdao University, Qingdao, China.
Endocr Res ; 47(1): 32-38, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1364665
ABSTRACT

PURPOSE:

The purpose of this study is to review observational studies on the effect of insulin use and mortality in patients with COVID-19 and diabetes.

METHODS:

A systematic literature search was performed using the PubMed, Medline, EMBASE, and Cochrane Library databases. The meta-analysis was performed using a random effects model, and I2 was applied to evaluate heterogeneity. Sensitivity and subgroup analyses were also performed.

RESULTS:

Overall, 1,338 patients over six studies were ultimately included. Insulin use was related to a higher risk of death in diabetic patients with COVID-19 compared to those who did not use insulin (odds ratio 2.59, 95% confidence interval 1.66-4.05; P < .0001; I2 57%).

CONCLUSIONS:

This meta-analysis revealed a correlation between insulin usage and increased mortality in diabetic patients with COVID-19. These results showed that insulin requirement in patients with COVID-19 and diabetes might indicate a poor prognosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Endocr Res Journal subject: Endocrinology Year: 2022 Document Type: Article Affiliation country: 07435800.2021.1967376

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Endocr Res Journal subject: Endocrinology Year: 2022 Document Type: Article Affiliation country: 07435800.2021.1967376