Your browser doesn't support javascript.
Evaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: In vitro and in vivo.
Almanza-Reyes, Horacio; Moreno, Sandra; Plascencia-López, Ismael; Alvarado-Vera, Martha; Patrón-Romero, Leslie; Borrego, Belén; Reyes-Escamilla, Alberto; Valencia-Manzo, Daniel; Brun, Alejandro; Pestryakov, Alexey; Bogdanchikova, Nina.
  • Almanza-Reyes H; Cluster de Bioeconomía de Baja California, A.C., Tijuana, Baja California, Mexico.
  • Moreno S; National Research Institute for Agricultural and Food Technology, Valdeolmos, Madrid, Spain.
  • Plascencia-López I; Faculty of Accounting and Administration, Autonomous University of Baja California, Tijuana, Baja California, Mexico.
  • Alvarado-Vera M; Cluster de Bioeconomía de Baja California, A.C., Tijuana, Baja California, Mexico.
  • Patrón-Romero L; Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Baja California, Mexico.
  • Borrego B; National Research Institute for Agricultural and Food Technology, Valdeolmos, Madrid, Spain.
  • Reyes-Escamilla A; Tijuana General Hospital, Tijuana, Baja California, Mexico.
  • Valencia-Manzo D; Tijuana General Hospital, Tijuana, Baja California, Mexico.
  • Brun A; Nursing Postgraduate, Iberoamericana University, Tijuana, Baja California, México.
  • Pestryakov A; National Research Institute for Agricultural and Food Technology, Valdeolmos, Madrid, Spain.
  • Bogdanchikova N; Tomsk Polytechnic University, Tomsk, Russia.
PLoS One ; 16(8): e0256401, 2021.
Article in English | MEDLINE | ID: covidwho-1365430
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
SARS-CoV-2 infection in hospital areas is of a particular concern, since the close interaction between health care personnel and patients diagnosed with COVID-19, which allows virus to be easily spread between them and subsequently to their families and communities. Preventing SARS-CoV-2 infection among healthcare personnel is essential to reduce the frequency of infections and outbreaks during the pandemic considering that they work in high-risk areas. In this research, silver nanoparticles (AgNPs) were tested in vitro and shown to have an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, we assess the effects of mouthwash and nose rinse with ARGOVIT® silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high-risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19. We present a prospective randomized study of 231 participants that was carried out for 9 weeks (during the declaration of a pandemic). The "experimental" group was instructed to do mouthwash and nose rinse with the AgNPs solution; the "control" group was instructed to do mouthwashes and nose rinse in a conventional way. The incidence of SARS-CoV-2 infection was significantly lower in the "experimental" group (two participants of 114, 1.8%) compared to the "control" group (thirty-three participants of 117, 28.2%), with an 84.8% efficiency. We conclude that the mouth and nasal rinse with AgNPs helps in the prevention of SARS-CoV-2 infection in health personnel who are exposed to patients diagnosed with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Silver / Health Personnel / Metal Nanoparticles / SARS-CoV-2 / COVID-19 / Mouthwashes Subject: Silver / Health Personnel / Metal Nanoparticles / SARS-CoV-2 / COVID-19 / Mouthwashes Type of study: Controlled clinical trial / Observational study Language: English Journal: PLoS One Clinical aspect: Etiology Year: 2021

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Silver / Health Personnel / Metal Nanoparticles / SARS-CoV-2 / COVID-19 / Mouthwashes Subject: Silver / Health Personnel / Metal Nanoparticles / SARS-CoV-2 / COVID-19 / Mouthwashes Type of study: Controlled clinical trial / Observational study Language: English Journal: PLoS One Clinical aspect: Etiology Year: 2021
...