A fem study of molecular transport through a single nanopore in a spherical cell
Biointerface Research in Applied Chemistry
; 12(3):2958-2969, 2022.
Article
in English
| Scopus | ID: covidwho-1365966
ABSTRACT
Electroporation has a specific application in the delivery of drugs into the cells. In addition, the challenge is to be able to deliver the drugs effectively. The key to the electroporation-based delivery method is regulated induced transmembrane voltage (ITMV). Recently, with the advent of COVID-19, there has been an increase in clinical trials on the delivery of DNA plasmids by electroporation. As a result, the substantial number of laboratory experiments are not feasible, thereby increasing the dependency on simulation-based research. Simulations of delivery of extracellular material into the cell depend upon molecular transport modeling in an electroporated cell. In this paper, molecular transport through a single nanopore is being studied theoretically. The closed-form expression of molecular transport is used in COMSOL Multiphysics simulation to obtain extracellular concentration variation as a function of time. Sinusoidal pulses with the varying magnitude of electric field (8kV/cm and 10 kV/cm) and time duration were used to understand pulse parameters' effect on molecular transport. The simulation results match the empirical result from the literature hence validate the simulation study. © 2021 by the authors.
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Biointerface Research in Applied Chemistry
Year:
2022
Document Type:
Article
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