2-Deoxy-d-glucose exploits increased glucose metabolism in cancer and viral-infected cells: Relevance to its use in India against SARS-CoV-2.
IUBMB Life
; 73(10): 1198-1204, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1366237
ABSTRACT
Mechanisms discovered to drive increased glucose metabolism in cancer cells are found to be similar to those in viral-infected cells. In this mini review, we summarize the major pathways by which the sugar analog, 2-Deoxy-d-glucose, has been shown to exploit increased glucose metabolism in cancer and how this information applies to viral-infected cells. Moreover, we highlight the relevance of these findings to the emergency approval of 2-Deoxy-d-glucose in India to be used against SARS-CoV-2, the virus responsible for COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Deoxyglucose
/
SARS-CoV-2
/
COVID-19
/
Glucose
/
Neoplasms
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
IUBMB Life
Journal subject:
Molecular Biology
/
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Iub.2546
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