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EDTA-Induced Pseudothrombocytopenia up to 9 Months after Initial COVID-19 Infection Associated with Persistent Anti-SARS-CoV-2 IgM/IgG Seropositivity.
Bereczki, Dániel; Nagy, Béla; Kerényi, Adrienne; Nagy, Gábor; Szarka, Krisztina; Kristóf, Katalin; Szalay, Balázs; Vásárhelyi, Barna; Bhattoa, Harjit P; Kappelmayer, János.
  • Bereczki D; Department of Neurology, Semmelweis University, Budapest, Hungary.
  • Nagy B; MTA-SE Neuroepidemiological Research Group ELKH, Budapest, Hungary.
  • Kerényi A; EANcore COVID-19 Task Force, European Academy of Neurology, Vienna, Austria.
  • Nagy G; Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Szarka K; Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Kristóf K; Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
  • Szalay B; Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Vásárhelyi B; Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  • Bhattoa HP; Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
  • Kappelmayer J; Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
Lab Med ; 53(2): 206-209, 2022 Mar 07.
Article in English | MEDLINE | ID: covidwho-1367036
ABSTRACT
Platelets have a role in vascular complications of COVID-19-related viral coagulopathy. Although immune-induced thrombocytopenia has been described mostly in moderate-to-severe COVID-19, the prognostic role of platelet count in COVID-19 is still controversial. Pseudothrombocytopenia has been reported to represent COVID-19-associated coagulopathy in critical illness, and transient EDTA-dependent pseudothrombocytopenia lasting less than 3 weeks was described in a patient with severe acute COVID-19 pneumonia. In our case study, EDTA-induced pseudothrombocytopenia was still present at 9 months after an initial SARS-CoV-2 virus infection in an apparently recovered 60 year old man. The persistence of antinucleocapside and antispike antibodies 9 months after the initial infection suggests that EDTA-induced pseudothrombocytopenia may be related to anti-SARS-CoV-2 IgG or IgM antibodies. We should acknowledge the possibility that pseudothrombocytopenia may also appear in some patients after seroconversion after the launch of large-scale vaccination programs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Limits: Humans / Male / Middle aged Language: English Journal: Lab Med Year: 2022 Document Type: Article Affiliation country: Labmed

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Limits: Humans / Male / Middle aged Language: English Journal: Lab Med Year: 2022 Document Type: Article Affiliation country: Labmed