Repurposing Colchicine in Treating Patients with COVID-19: A Systematic Review and Meta-Analysis.
Life (Basel)
; 11(8)2021 Aug 23.
Article
in English
| MEDLINE | ID: covidwho-1367867
ABSTRACT
Coronavirus disease 2019 (COVID-19) had caused huge health losses worldwide. Several drugs had been applied to treat patients with COVID-19, and repurposing colchicine had been proposed for its anti-inflammatory properties via several pathways. In this systematic review, we evaluated the effects of colchicine treatment. From inception to May 31, 2021, databases, including PubMed, EMbase, medRxiv, and Research Square were searched, and 11 studies were enrolled. A total of 17,205 COVID-19 patients with male predominance (62.9%) were analyzed. Patients with colchicine treatment had a significantly lower risk of mortality (odds ratio (OR) 0.57, 95% confidence interval (CI) 0.38-0.87, I2 72%; p < 0.01) and a non-significantly lower rate of mechanical ventilation (OR 0.67, 95%CI 0.39-1.15). The side effects were mild and not significantly different (OR 2.03, 95%CI 0.51-8.09). Subgroup analysis with randomized controlled trials showed no statistically significant difference in the mortality (OR 0.80, 95%CI 0.44-1.46, I2 33%; p = 0.22). In conclusion, our meta-analysis found that colchicine treatment was associated with a significantly lower risk of mortality in patients with COVID-19. However, this benefit was not observed in the subgroup analysis of randomized controlled trials. Further randomized controlled studies are required to confirm the potential benefits of colchicine treatment.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Life11080864
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