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The triad: respiratory microbiome - virus - immune response in the pathophysiology of pulmonary viral infections.
Porto, Bárbara N; Moraes, Theo J.
  • Porto BN; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Moraes TJ; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
Expert Rev Respir Med ; 15(5): 635-648, 2021 05.
Article in English | MEDLINE | ID: covidwho-1369023
ABSTRACT

INTRODUCTION:

The longstanding dogma that the healthy lung is sterile has been refuted by recent advances in culture-independent analyses of airway samples. The respiratory microbiome comprises all airway and lung tissue-associated microbes. These micro-organisms occur throughout the upper and lower respiratory tracts, with different populations and distinct burdens at specific sites and can be classified as pathogenic or commensal. AREAS COVERED The majority of studies investigating the respiratory microbiome have focused on bacteria; however, emerging evidence has revealed the composition of the lung virome, the global viral communities present in the lung tissue. In this review, we searched PubMed and used keywords such as airway microbiome. We restricted outputs to English language and did not limit by any dates. We summarize the up-to-date knowledge on how the microbiome interacts with the host immune system and influences the pathogenesis of pulmonary viral infections. EXPERT OPINION The relationship between colonizing microbes and the host is complex and various factors need to be considered in order to appreciate its pathophysiological consequences. Understanding these intricate mechanisms of interaction among the respiratory microbiome, viruses and the immune response may lead to the development of better therapies to treat or prevent respiratory viral infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / Virus Diseases / Microbiota Type of study: Reviews Limits: Humans Language: English Journal: Expert Rev Respir Med Year: 2021 Document Type: Article Affiliation country: 17476348.2021.1893168

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / Virus Diseases / Microbiota Type of study: Reviews Limits: Humans Language: English Journal: Expert Rev Respir Med Year: 2021 Document Type: Article Affiliation country: 17476348.2021.1893168