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Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration.
Gouma, Sigrid; Weirick, Madison E; Bolton, Marcus J; Arevalo, Claudia P; Goodwin, Eileen C; Anderson, Elizabeth M; McAllister, Christopher M; Christensen, Shannon R; Dunbar, Debora; Fiore, Danielle; Brock, Amanda; Weaver, JoEllen; Millar, John; DerOhannessian, Stephanie; Unit, The UPenn Covid Processing; Frank, Ian; Rader, Daniel J; Wherry, E John; Hensley, Scott E.
  • Gouma S; Department of Microbiology.
  • Weirick ME; Department of Microbiology.
  • Bolton MJ; Department of Microbiology.
  • Arevalo CP; Department of Microbiology.
  • Goodwin EC; Department of Microbiology.
  • Anderson EM; Department of Microbiology.
  • McAllister CM; Department of Microbiology.
  • Christensen SR; Department of Microbiology.
  • Dunbar D; Division of Infectious Diseases.
  • Fiore D; Department of Psychiatry.
  • Brock A; Institute for Translational Medicine and Therapeutics, and.
  • Weaver J; Institute for Translational Medicine and Therapeutics, and.
  • Millar J; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • DerOhannessian S; Institute for Translational Medicine and Therapeutics, and.
  • Unit TUCP; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Frank I; The UPenn COVID Processing Unit is detailed in Supplemental Acknowledgments.
  • Rader DJ; Division of Infectious Diseases.
  • Wherry EJ; Institute for Translational Medicine and Therapeutics, and.
  • Hensley SE; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
JCI Insight ; 6(16)2021 08 23.
Article in English | MEDLINE | ID: covidwho-1369459
ABSTRACT
Some studies suggest that recent common coronavirus (CCV) infections are associated with reduced COVID-19 severity upon SARS-CoV-2 infection. We completed serological assays using samples collected from health care workers to identify antibody types associated with SARS-CoV-2 protection and COVID-19 symptom duration. Rare SARS-CoV-2 cross-reactive antibodies elicited by past CCV infections were not associated with protection; however, the duration of symptoms following SARS-CoV-2 infections was significantly reduced in individuals with higher common betacoronavirus (ßCoV) antibody titers. Since antibody titers decline over time after CCV infections, individuals in our cohort with higher ßCoV antibody titers were more likely recently infected with common ßCoVs compared with individuals with lower antibody titers. Therefore, our data suggest that recent ßCoV infections potentially limit the duration of symptoms following SARS-CoV-2 infections through mechanisms that do not involve cross-reactive antibodies. Our data are consistent with the emerging hypothesis that cellular immune responses elicited by recent common ßCoV infections transiently reduce symptom duration following SARS-CoV-2 infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / Betacoronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / Betacoronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article