αvß6-Targeted Molecular PET/CT Imaging of the Lungs After SARS-CoV-2 Infection.
J Nucl Med
; 61(12): 1717-1719, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-1369627
ABSTRACT
The true impact and long-term damage to organs such as the lungs after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be determined. Noninvasive molecularly targeted imaging may play a critical role in aiding visualization and understanding of the systemic damage. We have identified αvß6 as a molecular target; an epithelium-specific cell surface receptor that is low or undetectable in healthy adult epithelium but upregulated in select injured tissues, including fibrotic lung. Herein we report the first human PET/CT images using the integrin αvß6-binding peptide (18F-αvß6-BP) in a patient 2 mo after the acute phase of infection. Minimal uptake of 18F-αvß6-BP was noted in normal lung parenchyma, with uptake being elevated in areas corresponding to opacities on CT. This case suggests that 18F-αvß6-BP PET/CT is a promising noninvasive approach to identify the presence and potentially monitor the persistence and progression of lung damage.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Integrins
/
Positron Emission Tomography Computed Tomography
/
COVID-19
/
Lung
/
Antigens, Neoplasm
Type of study:
Case report
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
J Nucl Med
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS