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Olfactory sensory evaluation in newborn children of women infected with COVID-19 during pregnancy
COVID-19 newborn odores odors perception percepção recém-nascido SARS-CoV-2 ; 2021(Journal of Human Growth and Development)
Article in English | WHO COVID | ID: covidwho-1370027
ABSTRACT

Introduction:

In adults, olfactory loss is one of the earliest and most frequent acute clinical manifestations of SARS-CoV-2 infection. The number of children infected with SARS-CoV-2 is relatively small, perhaps due to the lower expression of Angiotensin Converting Enzyme 2 (ACE2) in children compared to adults. Little is known about foetal impairment in mothers infected with SARS-CoV-2. This paper describes an ongoing scientific project on smell perception in infants.

Objective:

The goal of the study is to develop and validate a behavioural evaluative scale of olfactory perception in healthy newborns and to apply this scale to newborn children of women infected with COVID-19 during pregnancy comparing to newborn children of women without COVID-19 infection history, in order to compare these groups.

Methods:

This is a retrospective comparative analytical cohort study of 300 newborns exposed and unexposed to COVID-19 during pregnancy. The data collection will follow the experimental procedure in a previous study that explored odours of the maternal breastmilk, vanilla (sweet) and distilled water (neutral). A coffee smell was implemented as an addition to this previous study in order to include acid/bitterness category to the categories of stimuli.

Discussion:

It is feasible to argue the hypothesis of the involvement of the foetus' olfactory bulb as one of the indelible pathophysiological manifestations to the clinical diagnosis of COVID-19 with neurosensory olfactory deficit in foetuses and newborns affected by intrauterine infection. This study aims to investigate if newborn children of women infected with COVID-19 during pregnancy have olfactory sensory changes. The clinical trial was registered in the Brazilian Registry of Clinical Trials (ReBEC- RBR-65qxs2). © 2021 The authors. All Rights Reserved.
Full text: Available Collection: Databases of international organizations Database: WHO COVID Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: COVID-19 newborn odores odors perception percepção recém-nascido SARS-CoV-2 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: WHO COVID Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: COVID-19 newborn odores odors perception percepção recém-nascido SARS-CoV-2 Document Type: Article