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Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity.
Roberts, Lydia M; Schwarz, Benjamin; Speranza, Emily; Leighton, Ian; Wehrly, Tara; Best, Sonja; Bosio, Catharine M.
  • Roberts LM; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
  • Schwarz B; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
  • Speranza E; Lymphocyte Biology Section, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
  • Leighton I; Innate Immunity and Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT, USA.
  • Wehrly T; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
  • Best S; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
  • Bosio CM; Innate Immunity and Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT, USA.
iScience ; 24(9): 103025, 2021 Sep 24.
Article in English | MEDLINE | ID: covidwho-1370208
ABSTRACT
Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar metabolites underlie the establishment of trained innate immunity. Therefore, host metabolism and this response are intimately linked. However, little is known regarding the influence of lipids on the development and function of trained immunity. Utilizing two models of pulmonary bacterial infection combined with multi-omic approaches, we identified persistent, pathogen-specific changes to the lung lipidome that correlated with differences in the trained immune response against a third unrelated pathogen. Further, we establish the specific cellular populations in the lung that contribute to this altered lipidome. Together these results expand our understanding of the pulmonary trained innate immune response and the contributions of host lipids in informing that response.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.103025

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: IScience Year: 2021 Document Type: Article Affiliation country: J.isci.2021.103025