Biomaterials, biological molecules, and polymers in developing vaccines.
Trends Pharmacol Sci
; 42(10): 813-828, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1370313
ABSTRACT
Vaccines have been used to train the immune system to recognize pathogens, and prevent and treat diseases, such as cancer, for decades. However, there are continuing challenges in their manufacturing, large-scale production, and storage. Some of them also show suboptimal immunogenicity, requiring additional adjuvants and booster doses. As an alternate vaccination strategy, a new class of biomimetic materials with unique functionalities has emerged in recent years. Here, we explore the current bioengineering techniques that make use of hydrogels, modified polymers, cell membranes, self-assembled proteins, virus-like particles (VLPs), and nucleic acids to deliver and develop biomaterial-based vaccines. We also review design principles and key regulatory issues associated with their development. Finally, we critically assess their limitations, explore approaches to overcome these limitations, and discuss potential future applications for clinical translation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Biomimetic Materials
Type of study:
Prognostic study
Topics:
Vaccines
Language:
English
Journal:
Trends Pharmacol Sci
Year:
2021
Document Type:
Article
Affiliation country:
J.tips.2021.07.006
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