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Analysis of serum cytokine and protective vitamin D levels in severe cases of COVID-19.
Bayraktar, Nihayet; Turan, Hamdiye; Bayraktar, Mehmet; Ozturk, Ali; Erdogdu, Hamza.
  • Bayraktar N; Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
  • Turan H; Department of Chest Diseases, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
  • Bayraktar M; Department of Medical Microbiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
  • Ozturk A; Department of Medical Microbiology, Faculty of Medicine, Nigde Omer Halisdemir University, Nigde, Turkey.
  • Erdogdu H; Department of Statistics, Faculty of Administration and Economics, Harran University, Sanliurfa, Turkey.
J Med Virol ; 94(1): 154-160, 2022 01.
Article in English | MEDLINE | ID: covidwho-1370370
ABSTRACT
In this study, we investigated the role and relationship between the cytokine profile and protective vitamin D by measuring their serum levels in COVID-19 intensive care unit patients with severe illnesses. A total of 74 patients were included in our study. Patients were divided into two groups. Patients in the COVID-19 group (n = 31) and individuals without a history of serious illness or infection were used as the control group (n = 43). The serum concentrations of interleukin-1 (IL-1), IL-6, IL-10, IL-21, and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assays. Levels of serum vitamin D were detected with Liquid chromatography-mass spectrometry methodologies. TNF-α, IL-1, IL-6, IL-10, IL-21, and vitamin D levels were measured in all patients. The serum cytokine levels in the COVID-19 patient group were significantly higher (151.59 ± 56.50, 140.37 ± 64.32, 249.02 ± 62.84, 129.04 ± 31.64, and 123.58 ± 24.49, respectively) than control groups. Serum vitamin D was also significantly low (6.82 ± 3.29) in patients in the COVID-19 group than the controls (21.96 ± 5.39). Regarding the correlation of vitamin D with cytokine levels, it was significantly variable. Our study shows that COVID-19 patients are associated with lower serum vitamin D and higher pro-inflammatory cytokines associated with increased virus presence. Our data provide more evidence of the anti-inflammatory effect of vitamin D on COVID-19 patients and the protective effects of vitamin D on risk were demonstrated.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Cytokines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27294

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Cytokines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27294