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The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.
Chen, Yinghu; Yao, Hangping; Fu, Junfen; Shu, Qiang; Chen, Zhimin; Wu, Nanping; Ye, Sheng; Wang, Wei; Ni, Yan; Shang, Shiqiang; Li, Wei; Zheng, Jishan; Li, Shibo; Hong, Liang; Zhang, Qi; Xu, Weize; Chen, Junsong; Fan, Lingyan; Cang, Xiaohui; Wang, Jianbing; Lu, Xiangyun; Cao, Qingyi.
  • Chen Y; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Yao H; The Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, China.
  • Fu J; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: fjf68@zju.edu.cn.
  • Shu Q; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: Shuqiang@zju.edu.cn.
  • Chen Z; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Wu N; The Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, China.
  • Ye S; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Wang W; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Ni Y; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Shang S; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Li W; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Zheng J; Infection Disease Department, Ningbo Women & Children's Hospital, Ningbo, China.
  • Li S; Infection Disease Department, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China.
  • Hong L; Infection Disease Department, Rui'an People's Hospital, Rui'an, China.
  • Zhang Q; Infection Disease Department, Affiliated Hospital of Jiaxing University, Jiaxin, China.
  • Xu W; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China.
  • Chen J; Respiratory Department, , Hangzhou, China.
  • Fan L; Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Cang X; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China; Institute of Genetics, and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, China.
  • Wang J; The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China; Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou, China.
  • Lu X; The Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, China.
  • Cao Q; The Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, China.
Int J Infect Dis ; 111: 347-353, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-2113590
ABSTRACT

AIMS:

To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.

METHODS:

This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected. Bioinformatics was used to analyze the features of SARS-CoV-2. Individuals were divided into 3 groups by the first-generation case Groups 1 (unclear), 2 (adult), and 3 (child). The secondary attack rate (SAR) and R0 were compared among the groups.

RESULTS:

The infection rate among 211 individuals was 64% (135/211). The SAR in Groups 2 and 3 was 71% (73/103) and 3% (1/30), respectively; the median R0 in Groups 2 and 3 was 2 (range 1-8) and 0 (range 0-1), respectively. Compared with adult cases, the SAR and R0 of pediatric cases were significantly lower (p<0.05). We obtained SARS-CoV-2 sequences from the same infant's throat and fecal samples at a two-month interval and found that the new spike protein A958D mutation detected in the stool improved thermostability theoretically.

CONCLUSIONS:

Children have lower ability to spread SARS-CoV-2. The new A958D mutation is a potential reason for its long residence in the intestine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans / Infant Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.08.036

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans / Infant Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.08.036