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Fibromyalgia: a new facet of the post-COVID-19 syndrome spectrum? Results from a web-based survey.
Ursini, Francesco; Ciaffi, Jacopo; Mancarella, Luana; Lisi, Lucia; Brusi, Veronica; Cavallari, Carlotta; D'Onghia, Martina; Mari, Anna; Borlandelli, Elena; Faranda Cordella, Jacopo; La Regina, Micaela; Viola, Pasquale; Ruscitti, Piero; Miceli, Marco; De Giorgio, Roberto; Baldini, Nicola; Borghi, Claudio; Gasbarrini, Alessandro; Iagnocco, Annamaria; Giacomelli, Roberto; Faldini, Cesare; Landini, Maria Paola; Meliconi, Riccardo.
  • Ursini F; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy francesco.ursini2@unibo.it.
  • Ciaffi J; Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Mancarella L; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Lisi L; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Brusi V; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Cavallari C; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • D'Onghia M; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Mari A; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Borlandelli E; Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Faranda Cordella J; Department of Experimental, Diagnostic and Specialty Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola-Malpighi, Bologna, Italy.
  • La Regina M; Clinical Trial Centre, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Viola P; Risk Management Unit, ASL 5 La Spezia, La Spezia, Italy.
  • Ruscitti P; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Miceli M; Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.
  • De Giorgio R; Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Baldini N; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
  • Borghi C; Biomedical Science and Technology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Gasbarrini A; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Iagnocco A; Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Giacomelli R; Academic Rheumatology Centre, MFRU and Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italy.
  • Faldini C; Unit of Allergology, Immunology, Rheumatology, Department of Medicine, Università Campus Bio-Medico di Roma, Roma, Italy.
  • Landini MP; 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Meliconi R; Scientific Direction, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
RMD Open ; 7(3)2021 08.
Article in English | MEDLINE | ID: covidwho-1370912
ABSTRACT

OBJECTIVE:

Postacute COVID-19 syndrome (PACS) is an emerging entity characterised by a large array of manifestations, including musculoskeletal complaints, fatigue and cognitive or sleep disturbances. Since similar symptoms are present also in patients with fibromyalgia (FM), we decided to perform a web-based cross-sectional survey aimed at investigating the prevalence and predictors of FM in patients who recovered from COVID-19.

METHODS:

Data were anonymously collected between 5 and 18 April 2021. The collection form consisted of 28 questions gathering demographic information, features and duration of acute COVID-19, comorbid diseases, and other individual's attributes such as height and weight. The American College of Rheumatology (ACR) Survey Criteria and the Italian version of the Fibromyalgia Impact Questionnaire completed the survey.

RESULTS:

A final sample of 616 individuals (77.4% women) filled the form 6±3 months after the COVID-19 diagnosis. Of these, 189 (30.7%) satisfied the ACR survey criteria for FM (56.6% women). A multivariate logistic regression model including demographic and clinical factors showed that male gender (OR 9.95, 95% CI 6.02 to 16.43, p<0.0001) and obesity (OR 41.20, 95% CI 18.00 to 98.88, p<0.0001) were the strongest predictors of being classified as having post-COVID-19 FM. Hospital admission rate was significantly higher in men (15.8% vs 9.2%, p=0.001) and obese (19.2 vs 10.8%, p=0.016) respondents.

CONCLUSION:

Our data suggest that clinical features of FM are common in patients who recovered from COVID-19 and that obesity and male gender affect the risk of developing post-COVID-19 FM.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Fibromyalgia / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Country/Region as subject: North America Language: English Year: 2021 Document Type: Article Affiliation country: Rmdopen-2021-001735

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Fibromyalgia / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Country/Region as subject: North America Language: English Year: 2021 Document Type: Article Affiliation country: Rmdopen-2021-001735