Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.
Genome Biol
; 22(1): 242, 2021 08 23.
Article
in English
| MEDLINE | ID: covidwho-1370944
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Quantitative Trait Loci
/
Receptors, CXCR6
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Genome Biol
Journal subject:
Molecular Biology
/
Genetics
Year:
2021
Document Type:
Article
Affiliation country:
S13059-021-02454-4
Similar
MEDLINE
...
LILACS
LIS