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Beta- and Novel Delta-Coronaviruses Are Identified from Wild Animals in the Qinghai-Tibetan Plateau, China.
Zhu, Wentao; Yang, Jing; Lu, Shan; Lan, Ruiting; Jin, Dong; Luo, Xue-Lian; Pu, Ji; Wu, Shusheng; Xu, Jianguo.
  • Zhu W; State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  • Yang J; State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  • Lu S; Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Lan R; Research Units of Discovery of Unknown Bacteria and Function, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  • Jin D; State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  • Luo XL; Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Pu J; Research Units of Discovery of Unknown Bacteria and Function, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  • Wu S; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Xu J; State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Virol Sin ; 36(3): 402-411, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1372824
ABSTRACT
Outbreaks of severe virus infections with the potential to cause global pandemics are increasingly concerning. One type of those commonly emerging and re-emerging pathogens are coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2). Wild animals are hosts of different coronaviruses with the potential risk of cross-species transmission. However, little is known about the reservoir and host of coronaviruses in wild animals in Qinghai Province, where has the greatest biodiversity among the world's high-altitude regions. Here, from the next-generation sequencing data, we obtained a known beta-coronavirus (beta-CoV) genome and a novel delta-coronavirus (delta-CoV) genome from faecal samples of 29 marmots, 50 rats and 25 birds in Yushu Tibetan Autonomous Prefecture, Qinghai Province, China in July 2019. According to the phylogenetic analysis, the beta-CoV shared high nucleotide identity with Coronavirus HKU24. Although the novel delta-CoV (MtCoV) was closely related to Sparrow deltacoronavirus ISU42824, the protein spike of the novel delta-CoV showed highest amino acid identity to Sparrow coronavirus HKU17 (73.1%). Interestingly, our results identified a novel host (Montifringilla taczanowskii) for the novel delta-CoV and the potential cross-species transmission. The most recent common ancestor (tMRCA) of MtCoVs along with other closest members of the species of Coronavirus HKU15 was estimated to be 289 years ago. Thus, this study increases our understanding of the genetic diversity of beta-CoVs and delta-CoVs, and also provides a new perspective of the coronavirus hosts.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phylogeny / Coronavirus / Animals, Wild Type of study: Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Journal: Virol Sin Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12250-020-00325-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phylogeny / Coronavirus / Animals, Wild Type of study: Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Journal: Virol Sin Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12250-020-00325-z