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Polyketone metabolites isolated from Rhodiola tibetica endohytic fungus Alternaria sp. HJT-Y7 and their SARS-CoV-2 virus inhibitory activitives.
Lu, Xuan; Tang, Xiao-Yuan; Wang, Hai-Xin; Huang, Wei-Jin; Feng, Wei-Xing; Feng, Bao-Min.
  • Lu X; College of Life Science and Biotechnology, Dalian University, Dalian 116622, China. Electronic address: luxuan@dlu.edu.cn.
  • Tang XY; College of Life Science and Biotechnology, Dalian University, Dalian 116622, China.
  • Wang HX; College of Life Science and Biotechnology, Dalian University, Dalian 116622, China.
  • Huang WJ; AIDS Department, Institute of Biological Products, China Food and Drug Testing Institute, Beijing 102629, China.
  • Feng WX; College of Life Science and Biotechnology, Dalian University, Dalian 116622, China.
  • Feng BM; College of Life Science and Biotechnology, Dalian University, Dalian 116622, China.
Bioorg Chem ; 116: 105309, 2021 11.
Article in English | MEDLINE | ID: covidwho-1372894
ABSTRACT
Six new polyketone metabolites, compounds (1-6) and seven known polyketone compounds (7-13) were isolated from Rhodiola tibetica endophytic fungus Alternaria sp. The structural elucidation of five new polyketone metabolites were elucidated on the basis of spectroscopic including 2D NMR and HRMS and spectrometric analysis. Inhibition rate evaluation revealed that compounds 1(EC50 = 0.02 mM), 3(EC50 = 0.3 mM), 6(EC50 = 0.07 mM), 8(EC50 = 0.1 mM) and 9(EC50 = 0.04 mM) had inhibitory effect on the SARS-CoV-2 virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Polymers / Alternaria / SARS-CoV-2 / Ketones Type of study: Experimental Studies Limits: Humans Language: English Journal: Bioorg Chem Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Polymers / Alternaria / SARS-CoV-2 / Ketones Type of study: Experimental Studies Limits: Humans Language: English Journal: Bioorg Chem Year: 2021 Document Type: Article