Your browser doesn't support javascript.
Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2.
Lee, Yeong-Geun; Kang, Kyung Won; Hong, Woojae; Kim, Yeon Hwa; Oh, Jen Taek; Park, Dae Won; Ko, Minsung; Bai, Yun-Feng; Seo, Young-Jin; Lee, Sang-Myeong; Kim, Hyunggun; Kang, Se Chan.
  • Lee YG; Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea. Electronic address: lyg629@nate.com.
  • Kang KW; Division of Biotechnology, College of Environmental and Bioresources, Jeonbuk National University, Iksan 54596, Republic of Korea. Electronic address: gp1900@naver.com.
  • Hong W; Department of Biomechatronic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Kim YH; Division of Biotechnology, College of Environmental and Bioresources, Jeonbuk National University, Iksan 54596, Republic of Korea. Electronic address: fgdkg3636@naver.com.
  • Oh JT; Division of Biotechnology, College of Environmental and Bioresources, Jeonbuk National University, Iksan 54596, Republic of Korea. Electronic address: ojt3414@naver.com.
  • Park DW; Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea. Electronic address: dw@nmr.kr.
  • Ko M; Department of Biomechatronic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Bai YF; China Zhonggunacun Precision Medicine Science and Technology Foundation of Hepatology Center, Beijing 100039, China.
  • Seo YJ; Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea. Electronic address: yjseo@cau.ac.kr.
  • Lee SM; College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea. Electronic address: smlee@chungbuk.ac.kr.
  • Kim H; Department of Biomechatronic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: hkim.bme@skku.edu.
  • Kang SC; Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea. Electronic address: sckang@khu.ac.kr.
Bioorg Med Chem ; 45: 116329, 2021 09 01.
Article in English | MEDLINE | ID: covidwho-1372898
ABSTRACT
Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-ß-d-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Biological Products / Plant Extracts / Agrimonia / SARS-CoV-2 / COVID-19 Drug Treatment Topics: Variants Limits: Humans Language: English Journal: Bioorg Med Chem Journal subject: Biochemistry / Chemistry Year: 2021 Document Type: Article

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Biological Products / Plant Extracts / Agrimonia / SARS-CoV-2 / COVID-19 Drug Treatment Topics: Variants Limits: Humans Language: English Journal: Bioorg Med Chem Journal subject: Biochemistry / Chemistry Year: 2021 Document Type: Article